电子邮箱huangch268@mail.sysu.edu.cn
教育背景
2018.09-2024.06：上海交通大学，基础医学院，基础医学，获医学博士学位
2014.09-2018.06：南方医科大学，基础医学院，医学实验技术，获理学学士学位
科研与学士工作经历
2024.11-至今：中山大学医学院，科研博士后
研究方向
1. 蛋白质翻译后修饰；
2. RNA代谢与肿瘤
项目经历
1. 国家自然科学基金委员会，面上项目，2023.01-2026.12，在研，课题研究任务负责人；
2. 国家自然基金委员会，重点项目，2023.01-2027.12，在研，参与；
3. 国家自然基金委员会，重点项目，2017.01-2021.12，期满，参与
著作
1. He J#, Huang C#, Guo Y#, Deng R#, Li L, Chen R, Wang Y, Huang J, Zheng J, Zhao X, Yu J. PTEN-mediated dephosphorylation of 53BP1 confers cellular resistance to DNA damage in cancer cells. Mol Oncol. 2024 Mar;18(3):580-605.
2. Li L#, Li J#, Chen R#, Huang C#, Zuo Y, Lu R, Liu X, Huang J, Wang Y, Zhao X, Cheng J, Zhao X, Du C, Yu J. Loss of Fbxo45 in AT2 cells leads to insufficient histone supply and initiates lung adenocarcinoma. Cell Death Differ. 2024 Dec 13.
3. Cao Y#, Huang C#, Zhao X, Yu J. Regulation of SUMOylation on RNA metabolism in cancers. Front Mol Biosci. 2023 Feb 24;10:1137215.
4. Fang J#, Zhang Y#, Huang C, Lu R, Yu J, Chen R, Wang Y, Zhao X, Yu J, Huang J. Glucose-mediated N-glycosylation of RPTPα affects its subcellular localization and Src activation. Oncogene. 2023 Mar;42(14):1058-1071.
5. Zhao X#, Cao Y, Lu R, Zhou Z, Huang C, Li L, Huang J, Chen R, Wang Y, Huang J, Cheng J, Zheng J, Fu Y, Yu J. Phosphorylation of AGO2 by TBK1 Promotes the Formation of Oncogenic miRISC in NSCLC. Adv Sci (Weinh). 2024 Apr;11(15):e2305541.
6. Liu X#, Lu R#, Yang Q, He J, Huang C, Cao Y, Zhou Z, Huang J, Li L, Chen R, Wang Y, Huang J, Xie R, Zhao X, Yu J. USP7 reduces the level of nuclear DICER, impairing DNA damage response and promoting cancer progression. Mol Oncol. 2024 Jan;18(1):170-189.
7. Hou G#, Zhao X#, Li L, Yang Q, Liu X, Huang C, Lu R, Chen R, Wang Y, Jiang B, Yu J. SUMOylation of YTHDF2 promotes mRNA degradation and cancer progression by increasing its binding affinity with m6A-modified mRNAs. Nucleic Acids Res. 2021 Mar 18;49(5):2859-2877.
8. Guo Y#, He J#, Zhang H#, Chen R#, Li L, Liu X, Huang C, Qiang Z, Zhou Z, Wang Y, Huang J, Zhao X, Zheng J, Chen GQ, Yu J. Linear ubiquitination of PTEN impairs its function to promote prostate cancer progression. Oncogene. 2022 Oct;41(44):4877-4892.
9. Zhang H#, Zhao X#, Guo Y#, Chen R, He J, Li L, Qiang Z, Yang Q, Liu X, Huang C, Lu R, Fang J, Cao Y, Huang J, Wang Y, Huang J, Chen GQ, Cheng J, Yu J. Hypoxia regulates overall mRNA homeostasis by inducing Met1-linked linear ubiquitination of AGO2 in cancer cells. Nat Commun. 2021 Sep 13;12(1):5416.
