科研博士后

电子邮箱：liux767@mail.sysu.edu.cn

教育背景：
2015.9-2019.6：东北林业大学，生命科学学院，生物技术，获得理学学士学位
2019.9-2024.6：中山大学，医学院，免疫学，获得理学博士学位

科研与学术工作经历：
2024.9-至今：中山大学医学院 科研博士后

研究方向：
1、病毒基因组学研究；
2、病毒进化研究；

项目经历：
1.国家重点研发计划, 2024.12至2027.11, 在研, 子课题研究任务负责人
2.深圳市专项项目, 2022至2023, 期满, 参与
3.深圳市科技计划新型冠状病毒肺炎疫情应急防治项目, 2020.7.28至2023.7.31期满, 参与

著作：
1. Yun Feng, Guopeng Kuang, Yuanfei Pan, Jing Wang, Weihong Yang, Wei-chen Wu, Hong Pan, Juan Wang, Xi Han, Lifen Yang, Gen-yang Xin, Yong-tao Shan, Qin- yu Gou, Xue Liu, Deyin Guo, Guodong Liang, Edward C Holmes, Zihou Gao, Mang Shi, Small mammals in a biodiversity hotspot harbor viruses of emergence risk, National Science Review, 2024, nwae463.

2. Ziyue Yang#, Yongtao Shan#, Xue Liu, Guowei Chen, Yuanfei Pan, Qinyu Gou, Jie Zou, Zilong Chang, Qiang Zeng, Chunhui Yang, Jianbin Kong, Yanni Sun, Shaochuan Li, Xu Zhang, Wei-chen Wu, Chunmei Li, Hong Peng, Edward C Holmes, Deyin Guo, Mang Shi, VirID: Beyond Virus Discovery—An Integrated Platform for Comprehensive RNA Virus Characterization, Molecular Biology and Evolution, 2024. 4(10), msae202.

3. Miao He#, Liu Cao#, Lihong Liu, Xu Jin, Birong Zheng, Xue Liu, Jiaxin Zhuang, Fushi Zhang, Zixiao Yang, Yanxi Ji, Tiefeng Xu, Siyao Huang, Junhai Chen, Luyang Xie, Kun Li, Panpan Hou, Jian Pan, Deyin Guo*, Chunmei Li*. Reconstitution of RNA cap methylation reveals different features of SARS‐CoV‐2 and SARS‐CoV methyltransferases, Journal of Medical Virology, 2024 Feb;96(2): e29411.

4. Liu L#, Du J#, Yang S#, Zheng B, Shen J, Huang J, Cao L, Huang S, Liu X, Guo L, Li C, Ke C, Peng X, Guo D*, Peng H*. SARS-CoV-2 ORF3a sensitizes cells to ferroptosis via Keap1-NRF2 axis. Redox Biol. 2023 Jul; 63: 102752.

5. Ma Y#, Li P#, Hu Y#, Qiu T, Wang L, Lu H, Lv K, Xu M, Zhuang J, Liu X, He S, He B, Liu S, Liu L, Wang Y, Yue X, Zhai Y, Luo W, Mai H, Kuang Y, Chen S, Ye F, Zhou N, Zhao W, Chen J, Chen S, Xiong X, Shi M, Pan JA*, Chen YQ*. Spike substitution T813S increases Sarbecovirus fusogenicity by enhancing the usage of TMPRSS2. PLoS Pathog. 2023 May 17;19(5): e1011123.

6. Guo L#, Liu X#, Gu Y, Jiang J, Yang Z, Lv Q, Guo D, Yang Y*, Lu H*, Yuan J*. Distinct and relatively mild clinical characteristics of SARS-CoV-2 BA.5 infections against BA.2. Signal Transduct Target Ther. 2023 Apr 26;8(1):171.

7. Cao L#, Li Y#*, Yang S#, Li G#, Zhou Q#, Sun J#, Xu T, Yang Y, Liao R, Shi Y, Yang Y, Zhu T, Huang S, Ji Y, Cong F, Luo Y, Zhu Y, Luan H, Zhang H, Chen J, Liu X, Luo R, Liu L, Wang P, Yu Y, Xing F, Ke B, Zheng H, Deng X, Zhang W, Lin C, Shi M, Li CM, Zhang Y, Zhang L, Dai J, Lu H, Zhao J*, Zhang X*, Guo D*. The adenosine analog prodrug ATV006 is orally bioavailable and has preclinical efficacy against parental SARS-CoV-2 and variants. Sci Transl Med. 2022 Sep 7;14(661): eabm7621.

8. Jin Y, Ouyang M, Yu T, Zhuang J, Wang W, Liu X, Duan F, Guo D, Peng X*, Pan JA*. Genome-Wide Analysis of the Indispensable Role of Non-structural Proteins in the Replication of SARS-CoV-2. Front Microbiol. 2022 Jun 1; 13: 907422.

9. Wu J#, Zhong Y#, Liu X, Lu X, Zeng W, Wu C, Xing F, Cao L, Zheng F, Hou P, Peng H, Li C, Guo D#. A novel phosphorylation site in SARS-CoV-2 nucleocapsid regulates its RNA-binding capacity and phase separation in host cells. J Mol Cell Biol. 2022 May 20;14(2): mjac003.

10. Cao L#, Xu T#, Liu X#, Ji Y, Huang S, Peng H, Li C, Guo D*. The Impact of Accumulated Mutations in SARS-CoV-2 Variants on the qPCR Detection Efficiency. Front Cell Infect Microbiol. 2022 Jan 28; 12:823306.

11. Liu X, Guo L, Xu T, Lu X, Ma M, Sheng W, Wu Y, Peng H, Cao L, Zheng F, Huang S, Yang Z, Du J, Shi M*, Guo D*. A comprehensive evolutionary and epidemiological characterization of insertion and deletion mutations in SARS-CoV-2 genomes. Virus Evol. 2021 Dec 13;7(2): veab104.

12.Guo L#, Lu X#, Liu X, Li P, Wu J, Xing F, Peng H, Xiao X, Shi M, Liu Z, Li XD*, Guo D*. Meta-Transcriptomic Analysis Reveals the Virome and Viral Genomic Evolution of Medically Important Mites. J Virol. 2020 Mar 15;94(6): e01686-20.

13. 施莽; 刘学; 孔健斌; 郭德银. 基于相关性的分节段RNA病毒发现软件 [简称：SegFinder] 1.0, 登记号: 2024SR0816247. (软著)

14. 施莽; 刘学; 孔健斌; 郭德银; 李少川; 赵文婧. 一种基于宏转录组测序分析分节段 RNA 病毒的方法及其应用, 申请号: 202410527591.1. (发明专利已授权)