简介

硕士生导师,中山大学附属第八医院医学研究中心副研究员,深圳市高层次引进人才。长期从事衰老相关性疾病发病机制研究和抗衰老小分子药物开发,相关研究成果以第一或共一作者在Nucleic Acids Research、Signal Transduction and Targeted Therapy、Cancer Immunology Research等国际期刊上发表多篇SCI论文。获得8项中国发明专利授权和1项澳大利亚发明专利授权。先后主持国自然面上项目、国自然青年项目、广东省面上项目等基金项目共10项。获得中华医学科技奖、深圳市科技进步奖等5项科技奖励。现任广东省医学教育协会泛血管疾病专业委员会常务委员。

 

发表论文/著作

(1) Chen Yanlian ; Xie Chen; Zheng Xiaohui ; Nie Xin; Wang Zining; Liu Haiying; Zhao Yong ; LIN28/let-7/PD-L1 Pathway as a Target for Cancer Immunotherapy., Cancer Imunology Research, 2019, 7(3): 487-497 (共一第一,IF=13.8,一区)
(2) Xie Chen; Chen Yanlian ; Luo Dongling; Zhuang Zhen; Jin Heping; Zhou Haoxian; Li Xiaocui ; Lin Haijun; Zheng Xiaohui ; Zhang Jing; Wang Peihui ; Zhao Jincun; Zhao Yong; Huang Hui; Therapeutic potential of C1632 by inhibition of SARS-CoV-2 replication and viral-induced inflammation through upregulating let-7, Signal Transduction and Targeted Therapy, 2021, 6(3):605-607 (共一第二,IF=39.9,一区,封面论文)
(3) Chen, Yanlian ; Deng, Zhiqiang; Jiang, Shuai ; Hu, Qian; Liu, Haiying; Zhou Songyang; Ma, Wenbin; Chen, Shi ; Zhao, Yong ; Human cells lacking coilin and Cajal bodies are proficient in telomerase assembly, trafficking and telomere maintenance, Nucleic Acids Research, 2015, 43(1):385-395 (唯一第一,IF=19.2,一区)
(4) Xie, Chen; Chen, Yan Lian ; Wang, Dong Fang; Wang, Yi Lin; Zhang, Tian Peng; Li, Hui;
Liang, Fu; Zhao, Yong; Zhang, Guang Ya ; SgRNA Expression of CRIPSR-Cas9 System Based on MiRNA Polycistrons as a Versatile Tool to Manipulate Multiple and Tissue-Specific Genome Editing, Scientific Reports, 2017, 7(1): 5795 (共一第二,IF=4.6,二区)
(5)Xiaoxue Li ; Aiting Liu; Chen Xie ; Yanlian Chen ; Kuan Zeng; Changming Xie ; Zhengzhipeng Zhang; Pei Luo; Hui Huang ; The transcription factor GATA6 accelerates vascular smooth muscle  cell senescence-related arterial calcification by counteracting the role of anti-aging factor SIRT6 and impeding DNA damage repair, Kidney International, 2024, 105(1): 115-131 (IF=19.6,一区)
(6)Liu, Aiting; Chen, Zhenwei; Li, Xiaoxue Li; Xie, Chen; Chen, Yanlian; Su, Xiaoyan; Chen, Ying; Zhang, Mengbi; Chen, Jie; Yang, Tiecheng; Shen, Jiangang; Huang, Hui*; C5a-C5aR1 induces endoplasmic reticulum stress to accelerate vascular calcification via PERK-eIF2α-ATF4-CREB3L1 pathway, Cardiovascular Research, 2023, 589(15): 1958-1965. (IF=10.8,一区)
(7)Jin Heping; Chen Yanlian; Ren Jian; Huang Junjiu; Zhao Yong;  Liu, Haiying*. TERC suppresses PD-L1 expression by downregulating RNA binding protein HuR, Science China Life Sciences, 2022 :1-12.(IF=9.1,一区)
(8)Zhou, Haoxian; Xie, Chen; Xie, Yujie; He, Yunru ; Chen, Yanlian ; Zhang, Canfeng ; Zhang, Yan ; Zhao, Yong*; Liu, Haiying*; UBQLN1 deficiency mediates telomere shortening and IPF through interacting with RPA1, PLoS Genetics, 2023, 19(7): 0-e1010856. (IF=6.02, 一区)
(9)Tang Hao#; Wang Hu#; Cheng Xiaolei#; Fan Xiuqin#; Yang Fan#; Zhang Mengmeng; Chen Yanlian; Tian Yuyang; Liu Cihang; Shao Dongxing; Jiang Bin; Dou Yali; Cong Yusheng; Xing Junyue; Zhang Xiaotian; Yi Xia; Zhou Songyang; Ma Wenbin; Zhao Yong; Wang Xian; Ma Jinbiao; Gorospe Myriam; Ju Zhenyu; Wang Wengong*; HuR regulates telomerase activity through TERC methylation, Nature Communications, 2018, 9(1): 2721(IF=16.6,一区)
(10)Ge Yuanlong; Wu Shu; Xue Yong; Tao Jun; Li Feng; Chen Yanlian; Liu Haiying; Ma Wenbin; Huang Junjiu; and Zhao Yong*; Preferential extension of short telomeres induced by low extracellular pH. Nucleic Acids Research. 2016, 30;44(17):8086-96. (IF=19.2,一区)