简介

中山大学副研究员，研究生导师，中山大学附属第七医院生物样本库主任，独立PI，深圳市海外高层次B类人才。从事化学生物学与精准医学交叉融合领域研究，主要集中在金属药物与人工纳米杂合生物系统的研发和肿瘤/微生物耐药逆转等研究，以及构建肿瘤类器官平台推动新药与临床药物的转化研究；发表SCI论文70余篇，其中以通讯/第一作者在Chem. Soc. Rev.、 Adv. Mater.、 Signal Transduct. Tar. Thera.、 Mol. Cancer、 Drug Resist Update.、 Adv. Sci.、 Small、 J. Nanobiotechnol.、 Cancer Lett.等高影响力学术期刊上发表论文30余篇，论文被引4000余次，H指数31；申请中国专利5项并授权3项，主持国自然面上等科研项目10项。

发表论文/著作

近三年代表性论文：
  1.The important role of lactylation in regulating DNA damage repair and tumor chemotherapy resistance. Jia Li, Zhe-Sheng Chen*, Yihang Pan*,  Leli Zeng*, Drug Resistance Updates, 2024, doi: 10.1016/j.drup.2024.101148. (最后通讯作者，中科院一区，IF：15.4)
  2.Patient derived cancer organoids model the response to HER2-CD3 bispecific antibody (BsAbHER2) generated from hydroxyapatite gene delivery system. Yuhong Liu†, Chen Wang†, Guochuang Chen†, Junzong Chen, Wei Chen, Kefeng Lei, Jia Li, Yihang Pan, You Li, Jing Zhao*, Binbin Li*, Di Tang*, Leli Zeng*, Cancer Letters, 2024, 597, 217043. (最后通讯作者，中科院一区，IF：9.1)
  3.DDR1 drives malignant progression of gastric cancer by suppressing HIF-1α ubiquitination and degradation. Zhewei Wei†, Jin Li†, Li Zhong†, Dongjie Yang†, Wuguo Li, Wei Chen, Hao Zhou, Yulong He*, Wu Song*, Boyan Wang*, Leli Zeng*, Advanced Science, 2024, DOI:10.1002/advs.202308395. (最后通讯作者，中科院一区，IF：14.3)
  4.Exosome circATP8A1 induces macrophage M2 polarization by regulating the miR-1-3p/STAT6 axis to promote gastric cancer progression. Cuncan Deng†, Mingyu Huo†, Hongwu Chu†, Xiaomei Zhuang†, Guofei Deng, Wenchao Li, Hongfa Wei, Leli Zeng*, Yulong He, Huashan Liu, Jia Li*, Changhua Zhang*, Hengxing Chen*, Molecular Cancer, 2024, 23,49. (共同通讯作者，中科院一区，IF：27.7)
  5.Pumilio1 regulates NPM3/NPM1 axis to promote PD-L1-mediated immune escape in gastric cancer. Han Wang†, Zhijun Zhou†, Junchang Zhang†, Tengfei Hao†, Pengliang Wang, Pei Wu, Rishun Su, Huan Yang, Guofei Deng, Songyao Chen, Liang Gu, Yulong He*, Leli Zeng*, Changhua Zhang*, Songcheng Yin*, Cancer Letters, 2024, 581, 216498. (共同通讯作者，中科院一区，IF：9.1)
  6.PUM1 Promotes Tumor Progression by Activating DEPTOR‐Meditated Glycolysis in Gastric Cancer. Songcheng Yin†, Huifang Liu†, Zhijun Zhou†, Xiaoyu Xu, Pengliang Wang, Wei Chen, Guofei Deng, Han Wang, Hong Yu, Liang Gu, Mingyu Huo, Min Li*, Leli Zeng*, Yulong He*, Changhua Zhang*, Advanced Science, 2023, 10(27), 2301190. (共同通讯作者，中科院一区，IF：14.3)
  7.Advancements in nanoparticle-based treatment approaches for skin cancer therapy. Leli Zeng†, BH Gowda†, Mohammed Gulzar Ahmed, Mohammed AS Abourehab, Zhe-Sheng Chen, Changhua Zhang*, Jia Li*, Prashant Kesharwani*, Molecular Cancer, 2023, 22(1), 10. (第一作者，中科院一区，IF：27.7)
  8.Metal-enriched HSP90 nanoinhibitor overcomes heat resistance in hyperthermic intraperitoneal chemotherapy used for peritoneal metastases. Qiang Wang†, Peng Liu†, Yingfei Wen, Kuan Li, Bo Bi, Bin-bin Li, Miaojuan Qiu, Shiqiang Zhang, You Li, Jia Li, Hengxing Chen, Yuan Yin, Leli Zeng*, Changhua Zhang*, Yulong He*, Jing Zhao*, Molecular Cancer, 2023, 22,1-20. (共同通讯作者，中科院一区，IF：27.7)
  9.Cycloruthenated Self‐Assembly with Metabolic Inhibition to Efficiently Overcome Multidrug Resistance in Cancers. Jia Li†, Leli Zeng†*, Zheng Wang, Hengxing Chen, Shuo Fang, Jinquan Wang, Chao‐Yun Cai, Enming Xing, Xinxing Liao, Zhi‐Wei Li, Charles R Ashby Jr, Zhe‐Sheng Chen*, Hui Chao*, Yihang Pan*, Advanced Materials, 2022, 34(1), 2100245. (共同第一及通讯作者，中科院一区，IF：27.4)
  10.An Enzyme‐Engineered Nonporous Copper (I) Coordination Polymer Nanoplatform for Cuproptosis‐Based Synergistic Cancer Therapy. Yuzhi Xu†, Si‐Yang Liu†, Leli Zeng*, Hansu Ma, Yanfei Zhang, Huihui Yang, Yuchen Liu, Shuo Fang, Jing Zhao, Yunsheng Xu, Charles R Ashby Jr, Yulong He*, Zong Dai*, Yihang Pan*, Advanced Materials, 2022, 34(43), 2204733. (共同通讯作者，中科院一区，IF：27.4)
  11.Advances in immunology and immunotherapy for mesenchymal gastrointestinal cancers. Bo Li†, Hui Chen†, Shaohua Yang†, Feng Chen, Liangliang Xu, Yan Li, Mingzhe Li, Chengming Zhu, Fangyuan Shao, Xinhua Zhang, Chuxia Deng*, Leli Zeng*, Yulong He*, Changhua Zhang*, Molecular Cancer, 2023, 22(1), 71. (共同通讯作者，中科院一区，IF：27.7)
  12.Engineering Bifunctional Calcium Alendronate Gene-Delivery Nanoneedle for Synergistic Chemo/Immuno-Therapy Against HER2 Positive Ovarian Cancer. Guochuang Chen†, Leli Zeng†, Bo Bi, Xiuyu Huang, Miaojuan Qiu, Ping Chen, Zhi‐Ying Chen, Yulong He, Yihang Pan*, Yu Chen*, Jing Zhao*, Advanced Science, 2023, 10(14), 2204654. (共同第一作者，中科院一区，IF：14.3)
  13.Inhibition of Phosphoglycerate dehydrogenase induces ferroptosis and overcomes enzalutamide resistance in castration-resistant prostate cancer cells. Jinxiang Wang†, Leli Zeng†, Nisha Wu, Yanling Liang, Jie Jin, Mingming Fan, Xiaoju Lai, Zhe-Sheng Chen, Yihang Pan*, Fangyin Zeng*, and Fan Deng*, Drug Resistance Updates, 2023, 70, 100985. (共同第一作者，中科院一区，IF：15.8)
  14.Enhanced mild-temperature photothermal therapy by pyroptosis-boosted ATP deprivation with biodegradable nanoformulation. Kaiyuan Liu†, Li Zhang†, Hengli Lu†, Yingfei Wen, Bo Bi, Guocheng Wang, Yingying Jiang*, Leli Zeng*, Jing Zhao*, Journal of Nanobiotechnology, 2023, 21(1), 64. (共同通讯作者，中科院一区，IF：10.6)
  15.Signaling pathways and therapeutic interventions in gastric cancer. Zi-Ning Lei†, Qiu-Xu Teng†, Qin Tian†, Wei Chen†, Yuhao Xie, Kaiming Wu, Qianlin Zeng, Leli Zeng*, Yihang Pan*, Zhe-Sheng Chen*, Yulong He*, Signal Transduction and Targeted Therapy, 2022, 7(1), 358. (共同通讯作者,中科院一区，IF：40.5)