个人简介
李乾，博士，中山大学医学院副教授，博士生导师，中山大学逸仙学者计划“新锐学者”。2016年从清华大学博士毕业后，先后以博士后（2016-2018）和研究系列教师身份（2018-2024）继续在清华大学生命科学学院、IDG/麦戈文脑科学研究院从事学习、记忆和遗忘的神经生物学机制研究。致力于发现和理解生物为了更好地适应环境变化而具备的主动记忆调控机制，包括用于对抗无关干扰的主动保护机制（Neuron, 2018; eLife, 2023）和用于信息更新的主动遗忘机制（Cell Reports, 2016; PNAS, 2019; Current Biology, 2025）。基于这些主动的记忆调控机制带来的新理解，也同时探索其在促进脑健康方面（Aging Cell, 2022; Current Biology, 2023）的潜在应用价值。目前已发表论文22篇，以第一或通讯作者（含共同）发表论文13篇，包括Neuron、PNAS、Current Biology、Aging Cell、 Cell Reports和eLife等国际知名杂志。

 

研究方向
1. 机制探索：大脑如何学习、记忆和遗忘？ 
2. 转化应用：如何利用基础研究的发现来促进脑健康与治疗脑疾病？

 

image-20241212115113-1

 

主持科研项目
中山大学高校基本科研业务费青年教师培育项目，59000-31610021，干扰引起的短期记忆遗忘的分子机制探究，2024， 5.5万
国家自然科学基金面上项目，31970955，基于遗忘机制的短期记忆再年轻化研究，2020-2023，59万
国家自然科学基金青年科学基金项，31700912，输入蛋白介导长时程记忆固化的分子机制研究，2018-2019，25万
中国博士后科学基金面上资助，2016M601004，新型老年痴呆症果蝇模型建立和评价，5万

 

招生招聘
本课题组长期招收博士研究生、硕士研究生和博士后。除生物学相关研究背景以外，也欢迎有强烈兴趣的不同学科背景人员加入团队。
招生专业：生物与医药（专硕）、神经生物学（学博）
 

 

联系方式
liqian255@mail.sysu.edu.cn
 

 

论文发表情况

 一作或通讯作者（含共同）

  1. Ning Huang#, Jun Zhou#, Yang Gao#, Yuwei Peng#, Wantong Hu, Guangshuo Ou, Qian Li*, Yi Zhong* (2025). Rapid memory shift between different synaptic ensembles promotes forgetting in Drosophila.Current Biology 35, 1-14.
  2. Jianjian Zhao, Xuchen Zhang, Bohan Zhao, Wantong Hu, Tongxin Diao, Liyuan Wang, Yi Zhong, Qian Li* (2023). Genetic dissection of mutual interference between two consecutive learning tasks in Drosophila. eLife 12.
  3. Qi Yang#, Jun Zhou#, Lingling Wang, Wantong Hu, Yi Zhong*, Qian Li* (2023). Spontaneous recovery of reward memory through active forgetting of extinction memory. Current Biology 33, 1-11.
  4. Bohan Zhao#, Xuchen Zhang#, Jianjian Zhao, Qian Li* (2022). Exclusion and Co-expression of Aversive Olfactory Long-Term Memories in Drosophila. Neuroscience bulletin 38, 657-660.
  5. Han Mo#, Linghan Wang#, Yuting Chen, Xuchen Zhang, Ning Huang, Tingting Liu, Wantong Hu, Yi Zhong, Qian Li* (2022). Age-related memory vulnerability to interfering stimuli is caused by gradual loss of MAPK-dependent protection in Drosophila. Aging cell 21, e13628.
  6. Tingting Liu#, Linghan Wang#, Qian Li* (2021). Drosophila Ortholog of Mammalian Immediate-Early Gene Npas4 is Specifically Responsive to Reversal Learning. Neuroscience bulletin 37, 99-102. 
  7. Lingling Wang#, Qi Yang#, Binyan Lu, Lianzhang Wang, Yi Zhong*, Qian Li* (2019). A behavioral paradigm to study the persistence of reward memory extinction in Drosophila. Journal of genetics and genomics46, 599-601. 
  8. Yang Gao#, Yichun Shuai#, Xuchen Zhang#, Yuwei Peng#, Lianzhang Wang, Jing He, Yi Zhong*, Qian Li* (2019). Genetic dissection of active forgetting in labile and consolidated memories in Drosophila. PNAS 116, 21191-21197. 
  9. Xuchen Zhang#, Qian Li#, *, Lianzhang Wang, Zhong-jian Liu, Yi Zhong* (2018). Active Protection: Learning-Activated Raf/MAPK Activity Protects Labile Memory fromRac1-Independent Forgetting, Neuron98, 142-155 e144. 
  10. Wantong Hu#, Yiqing Peng#, Jiameng Sun#, Fang Zhang, Xuchen Zhang, Lianzhang Wang, Qian Li*, Yi Zhong* (2018). Fan-Shaped Body Neurons in the Drosophila Brain Regulate Both Innate and Conditioned Nociceptive Avoidance. Cell reports 24, 1573-1584. 
  11. Wantong Hu#, Xuchen Zhang#, Lianzhang Wang, Zhong-jian Liu, Yi Zhong*, and Qian Li* (2017). Preferential distribution of nuclear MAPK signal in alpha/beta core neurons during long-term memory consolidation in Drosophila. Protein Cell 8, 780-783. 
  12. Xuchen Zhang#, Qian Li#, Lianzhang Wang, Zhong-jian Liu, Yi Zhong*, Cdc42-Dependent Forgetting Regulates Repetition Effect in Prolonging Memory Retention, Cell Reports, 2016, 16: 817-825.
  13. Qian Li#, Xuchen Zhang#, Wantong Hu#, Xitong Liang#, Fang Zhang, Lianzhang Wang, Zhong-Jian Liu, Yi Zhong*, Importin-7 mediates memory consolidation through regulation of nuclear translocation of training-activated MAPK in Drosophila,PNAS, 2016, 113: 3072-3077. 

  参与作者

  1. Liyuan Wang#, Xingxing Zhang#, Qian Li, Mingtian Zhang, Hang Su, Jun Zhu*, Yi Zhong*(2023). Incorporating neuro-inspired adaptabilityfor continual learning in artificial intelligence. Nature Machine Intelligence 5, 1356-1368. 
  2. Yu Duan, Zhongfan Jia, Qian Li, Yi Zhong*, Kaisheng Ma* (2023). Hebbian and Gradient-based Plasticity Enables Robust Memory and Rapid Learning in RNNs.ICLR. 
  3. Liyuan Wang#, Xingxing Zhang#, Qian Li, Jun Zhu*, Yi Zhong* (2022). CoSCL: Cooperation of Small Continual Learners is Stronger Than a Big One. ECCV. 
  4. Liyuan Wang, Bo Lei, Qian Li, Hang Su, Jun Zhu*, Yi Zhong* (2022). Triple-Memory Networks: A Brain-Inspired Method for Continual Learning. IEEE Transactions on Neural Networks and Learning Systems 33, 1925-1934. 
  5. Bohan Zhao#, Jiameng Sun#, Qian Li, Yi Zhong* (2021). Differential conditioning produces merged long-term memory in Drosophila. eLife 10. 
  6. Liyuan Wang, Mingtian Zhang, Zhongfan Jia, Qian Li, Kaisheng Ma, Chenglong Bao, Jun Zhu*, Yi Zhong* (2021). AFEC: Active Forgetting of Negative Transfer in Continual Learning, NeurIPS. 
  7. Bohan Zhao#, Jiameng Sun#, Xuchen Zhang, Han Mo, Yijun Niu, Qian Li, Lianzhang Wang, Yi Zhong* (2019). Long-term memory is formed immediately without the need for protein synthesis-dependent consolidation in Drosophila. Nature Communications 10, 4550. 
  8. Siqi Yin, Zhaochu Luo, Qian Li, Chengyue Xiong, Yunlong Liu, Rajan Singh, Fei Zeng, Yi Zhong, Xiaozhong Zhang* (2019). Emulation of Learning and Memory Behaviors by Memristor Based on Ag Migration on 2D MoS2 Surface. Phys Status Solidi A 216. 
  9. Li Lv#, Yunlong Liu#, Jianxin Xie#, Yan Wu, Jianjian Zhao, Qian Li, Yi Zhong* (2019). Interplay between alpha2-chimaerin and Rac1 activity determines dynamic maintenance of long-term memory. Nature Communications 10, 5313. 

 

 专著发表情况

  1. Qian Li  and Yi Zhong (2025). 2.03 - Remembering punishment-related odors: Insights from the Drosophila brain and its inspiration. In: Learning and Memory: A Comprehensive Reference (Third Edition), J. Wixted, ed. (Academic Press),pp. 30-42. https://doi.org/10.1016/B978-0-443-15754-7.00052-3