简介

2008年毕业于山西师范大学获得生物学学士学位，2014年毕业于香港中文大学获得化学病理学博士学位，并于2015-2019年先后在美国Fred Hutch癌症研究中心和香港大学医学院任职博士后，2019年10月通过中山大学“百人计划”加入中山大学附属第七医院。目前主持国家、省市级科研项目共6项。以第一/通讯作者发表研究论文共20篇，研究成果主要发表在Gastroenterology、Genes and Development、Cell Death and Disease、Drug Resistance Updates、Oncogene及Cellular and Molecular Life Sciences等杂志上，并担任Advanced Science、JCI Insight、Cellular and Molecular Life Sciences、International Journal of Biological Sciences、Cancer Letters等杂志审稿人。

发表论文/著作

1.    Zou, H., Luo, J., Guo, Y., Deng, L., Zeng, L., Pan, Y., Li, P. Tyrosine phosphorylation-mediated YAP1-TFAP2A interactions coordinate transcription and trastuzumab resistance in HER2+ breast cancer. Drug Resistance Updates (2024), 73: 101051.
2.    Tong, T., Huang, M., Yan, B., Lin, B., Yu, J., Teng, Q., Li, P*., Pang, J*. Hippo signaling modulation and its biological implications in urological malignancies. Molecular Aspects of Medicine (2024), 98:101280. (* Co-corresponding author).
3.    Luo, J., Deng, L., Zou, H., Guo, Y., Tong, T., Huang, M., Ling, G., Li, P. New insights into the ambivalent role of YAP/TAZ in human cancers. Journal of Experimental and Clinical Cancer Research (2023), 42(1):130.
4.    Zou, H., Luo, J., Guo, Y., Tong, T., Liu, Y., Chen, Y., Xiao, Y., Ye, L., Zhu, C., Deng, L., Wang, B., Pan, Y., Li, P. Tyrosine kinase SRC-induced YAP1-KLF5 module regulates cancer stemness and metastasis in triple-negative breast cancer. Cellular and Molecular Life Sciences (2023), 80(2):41.
5.    Luo, J., Zou, H., Guo, Y., Tong, T., Chen, Y., Xiao, Y., Pan, Y., Li, P. The oncogenic roles and clinical implications of YAP/TAZ in breast cancer. British Journal of Cancer (2023), 128(9):1611-1624.
6.    Guo, Y., Luo, J., Zou, H., Liu, C., Deng, L., Li, P. Context-dependent transcriptional regulation of YAP/TAZ in cancer. Cancer Letters (2022), 527: 164-173.
7.    Zou, H., Luo, J., Guo, Y., Liu, Y., Wang, Y., Deng, L., Li, P. RNA-binding protein complex LIN28/MSI2 enhances cancer stem cell-like properties by modulating Hippo-YAP1 signaling and independently of Let-7. Oncogene (2022), 41(11): 1657-1762.
8.    Luo, J., Zou, H., Guo, Y., Huang, K., Ngan, ESW., Li, P. BACE2 variant identified from HSCR patient causes AD-like phenotypes in hPSC-derived brain organoids. Cell Death Discovery (2022), 8(1):47.
9.    Tang, C#., Li, P#., Lai, F., Fu, A., Lau, S., So, M., Lui, K., Li, Z., Zhuang, X., Yu, M., Liu, X., Ngo, N., Miao, X., Zhang, X., Yi, B., Tang S., Sun, X., Zhang, F., Liu, H., Liu, Q., Zhang, R., Wang, H., Huang, L., Dong, X., Tou, J., Cheah, K., Yang, W., Yuan, Z., Yip, Y., Sham, P., Tam, P., Garcia-barcelo, M., Ngan, E. Identification of genes associated with Hirschsprung disease, based on whole-genome sequence analysis, and potential effects on enteric nervous system development. Gastroenterology (2018), 155, 1908-1922. (# Co-first author).
10.    Li, P#., Silvis, M#., Honaker, Y#., Lien, W.H., Arron, S., Vasioukhin, V. αE-catenin inhibits a novel Src-YAP1 oncogenic module that couples tyrosine kinases and the effector of Hippo signaling pathways. Genes and Development (2016), 30, 798-811. (# Co-first author).