个人简介:

周国影(PhDMD),中山大学博士生导师、副研究员、PI,中山大学“百人计划”海外高层次引进人才。主要从事肿瘤免疫和类器官的研究,共发表SCI论文16篇,其中以第一/通讯作者在国际权威学术期刊GastroenterologyJournal of HepatologyBritish journal of cancerOncoImmunologyInternational journal of cancer等发表7篇论文。以主要负责人身份参与荷兰基金项目2项(共约60万欧元),获得荷兰国家消化协会颁发的青年肝病学家奖以及荷兰Erasmus医学中心颁发的年度最佳发表奖。曾与知名医药企业美国Pfizer、荷兰Merus合作,多次在国际学术会议上做特邀和大会报告,并担任多个学术杂志审稿人。

 

教育背景:

2013/10-2017/09,荷兰鹿特丹伊拉斯姆斯大学(Erasmus University Rotterdam),博士

2012/09-2013/01,法国洛林大学医院,交流实习

2010/09-2011/01,法国南锡大学医院,交流实习

2006/09-2013/07,武汉大学,临床医学七年制法语班,学士和硕士

 

工作经历:

2022/06-至今,中山大学附属第七医院,科研中心,副研究员

2017/10-2021/12,荷兰伊拉斯姆斯医学中心(Erasmus Medical Center),博士后

 

研究方向:

周国影课题组需招聘博士后、助理研究员、实习研究员、博士和硕士学生。我们希望团队内部互相学习、互助互爱,自愿形成科研配伍合作关系,主要从事但不局限于以下三个方向的研究课题:

1. 肝细胞肝癌和胆管细胞癌等多种消化系统恶性肿瘤的免疫治疗;

2. 肝癌类器官与免疫细胞的三维共培养,其相互作用和相关机制;

3. 其他各种类型恶性肿瘤的免疫学研究,新型靶点和生物标志物。

 

代表论文

1. Zhou G#, et al. Modelling immune cytotoxicity for cholangiocarcinoma with tumour-derived organoids and effector T cells. British Journal of Cancer. 2022.

2. Zhou G#, et al. Immune suppressive checkpoint interactions in the tumour microenvironment of primary liver cancers. British Journal of Cancer. 2021. 

3. Zhou G, et al. Reduction of immunosuppressive tumor microenvironment in cholangiocarcinoma by ex vivo targeting immune checkpoint molecules. Journal of Hepatology. 2019.

4. Zhou G, et al. Blockade of LAG3 enhances responses of tumor-infiltrating T cells in mismatch repair-proficient liver metastasis of colorectal cancer. OncoImmunology. 2018.

5. Zhou G, et al. Antibodies Against Immune Checkpoint Molecules Restore Functions of Tumor-infiltrating T cells in Hepatocellular Carcinomas. Gastroenterology. 2017.

6. van Beek AA*, Zhou G*, et al. GITR ligation enhances functionality of tumor-infiltrating T cells in hepatocellular carcinoma. International Journal of Cancer. 2019. 

7. Wang H*, Zhou G*#, et al. Serological Screening for Celiac Disease in Adult Chinese Patients with Diarrhea Predominant Irritable Bowel Syndrome. Medicine (Baltimore). 2015.

8. Ge Z, Zhou G, et al. TIGIT and PD1 Co-blockade Restores ex vivo Functions of Human Tumor-Infiltrating CD8+ T Cells in Hepatocellular Carcinoma. Cellular and Molecular Gastroenterology and Hepatology. 2021.

9. Pedroza-Gonzalez A, Zhou G, et al. GITR engagement in combination with CTLA-4 blockade completely abrogates immunosuppression mediated by human liver tumor-derived regulatory T cells ex vivo. OncoImmunology. 2015.

10. Pedroza-Gonzalez A, Zhou G, et al. Tumor-infiltrating plasmacytoid dendritic cells promote immunosuppression by Tr1 cells in human liver tumors. OncoImmunology. 2015.

*共同第一作者,#通讯作者。

 

个人邮箱:

zhougy9@mail.sysu.edu.cn