中国科学技术大学神经生物学和生物物理学博士。日本大阪大学医学院、美国约翰霍普金斯大学医学院博士后。日本理化学研究所、脑科学综合研究中心《大脑皮层回路可塑性》研究组副组长兼研究员。2009年底中山大学“百人计划”引进受聘为中山医学院（广州）生理学系教授，博士研究生和博士后流动站导师。2023年加入中山大学医学院（深圳）。从事神经科学研究20余年。研究工作集中在分子和细胞水平上探讨感觉刺激改变后大脑感觉皮层突触可塑性发生调整的神经机制, 以及自闭症模型动物大脑神经环路可塑性的改变等。在神经科学专业期刊 Nature Neuroscience、Neuron、Molecular Psychiatry、Advance science、EMBO reports, Journal of Neuroscience以及Neuropharmacology 等主流杂志发表SCI论文20余篇。曾为Journal of Neuroscience, Frontiers in Cellular Neuroscience, Journal of Neurophysiology, Neuroscience，Brain research等杂志的审稿专家。现为Frontiers in Cellular Neuroscience编辑委员会评审编辑。

主要科研成果简介：

1，阐明Celsr2基因调节成年小鼠的社会记忆行为。Celsr2基因(钙粘蛋白EGF LAG7通g型受体2) 是一种蛋白编码基因， 参与神经系统发育过程的纤毛发生，神经元的迁移，轴突的生长和再生和树突发育，但成年后Celsr2基因调控动物何种行为至今没有探索。该研究采用Celsr2 全脑敲除小鼠 （Celsr2 KO），研究发现成年小鼠海马CA1中的Celsr2的缺失导致NMDAR介导的突触传递减少，CA1锥体神经元在识别同种动物时，细胞的放电活性降低，提示Celsr2 KO小鼠呈现社会记忆缺陷。Celsr2缺失导致海马CA1锥体神经元的树突过度生长和树突棘成熟障碍。在正常成年小鼠的背侧CA1中，Celsr2的选择性缺失再现了Celsr2 KO小鼠中观察到的突触功能障碍和社会记忆缺陷，表明Celsr2在维持成年海马回路的完整性中起重要作用。本文于2022年7月4日在线发表在Nature 旗下的子刊Molecular Psychiatry 上。

2，揭示了前额叶皮层中的eEF2促进兴奋性突触传递和社交新奇行为。真核,胞mRNA翻译延伸因子eEF2协调各种突触信号控制蛋白质合成，参与海马体依赖的认知功能。然而，大脑皮层不同区域的eEF2表达是否呈现功能的特异性尚不清楚。本文构建了一个eEF2杂合子(HET)小鼠的品系，结果显示杂合子(HET)小鼠前额叶皮层（mPFC）的兴奋性神经元中eEF2表达减少且整体蛋白质合成下降，树突棘密度下降，细胞兴奋性降低，mPFC第5层锥体神经元的AMPAR介导的突触传递受损。杂合子(HET)小鼠呈现出社交新奇行为缺陷和强烈的焦虑感，反之在野生型小鼠的mPFC兴奋性神经元中特异性敲除eEF2可损害社交新奇偏好。在HET小鼠的mPFC 上用化学遗传方法激活锥体细胞或局部输注AMPAR激动剂PF-4778574，均可以纠正HET小鼠的社交新奇行为缺陷。本研究的科学意义在于阐明了小鼠的mPFC 脑区的eEF2可促进锥体细胞的AMPAR介导的突触传递功能， 进而影响与mPFC 相关联的动物行为。该文2022年8月22日在线发表在EMBO reports上。

3，揭示了自闭症易感基因DOCK4调控社交行为的分子及细胞机制。Dock4 KO小鼠表现出社交行为、发声、焦虑水平以及学习和记忆异常。机理上研究发现：缺失Dock4 蛋白后，海马CA1神经元中的Rac1蛋白（Dock4的下游分子）调控的谷氨酸受体的蛋白合成下降，导致兴奋性突触传递功能降低和海马神经元树突棘的减少, 长时程增强（long-term potentiation, LTP）降低, 兴奋/抑制平衡趋向更强抑制。首次揭示了海马 CA1 兴奋性细胞突触后的AMPA 和 NMDA 受体的正常蛋白质合成由 Dock4 通过 Rac1调节，提出了依赖于 Dock4-Rac1调节海马兴奋性突触传递和社会行为的新机制。

4，首次报道在小鼠的视皮层上可以诱导出代谢性谷氨酸受体依赖性mGluR5-LTP。LTP发现40 多年来，对其诱导，突触前和突出后效应以及细胞内的分子机制都做了深入的研究。LTP可以在几乎所有的大脑的功能部位都被诱导出，被认为是学习记忆的分子基础，此外，在感觉皮层，它也被认为是外界感觉经验修饰感觉皮层内部突触功能的一种生理机制。在视皮层，适当地刺激第4层，在第2/3 层可诱导出NMDAR-LTP。 没有视觉经验小鼠[出生后放到暗室饲养（Dark rearing, DR）或在生后的任一年龄段放入暗室饲养（Dark exposure, DE） 呈现比有视觉经验的小鼠（正常饲养）较大的 NMDAR-LTP。然而，当暗室饲养的小鼠曝光10-12小时后，原先诱导的 LTP 却转成了 LTD （long-term depression）。出人意料的是，当加入APV后，这种 LTD 转成较大的 LTP。深入研究发现这种由小鼠获得视觉经验引起的LTP 是代谢性谷氨酸受体5介导的， 定义为 mGluR5-LTP。视皮层的这种新型的mGluR5-LTP是短暂的，它只出现在曝光后的6小时，10-12小时为高峰，16小时后即消失，并重新恢复到NMDAR-LTP。更有趣是: mGluR5-LTP 只发生在生后即可放入暗室，完全没有视觉经验再曝光的小鼠身上，不发生在之前已有视觉经验后放入暗室再曝光的小鼠身上。该发现的意义在于完全没有视觉经验的暗室饲养小鼠，在获得视觉经验的6-16小时期间可以诱导出 mGluR5-LTP。 推测这种短暂的 mGluR5-LTP 可能在视皮层细胞得到视觉刺激后，感受野特性的快速建立中起重要作用。该文发表在Journal of Neuroscience，2017，并被当期推荐为 featured article。

5，在成年动物中重新激活视皮层可塑性，便于弱视眼功能的改善一直是神经科学家和眼科医生的重要课题。 Cdk5是作为一种多功能激酶，参与神经细胞迁移、轴突导向、突触发生与传递。我们探索了阻断Cdk5是否能重新激活视皮层可塑性。腹腔注射Cdk5的抑制剂CP681301或病毒感染的方法阻断Cdk5基因表达，均可诱导出成年视皮层可塑性。尽管视皮层GABAA受体含量不变，但在成年视皮层重新诱导出年幼动物样的抑制性LTD（iLTD）以及幼年样的白质—第2/3 层的LTP，说明抑制Cdk5的作用是通过下调视皮层内部的抑制效应，从而重新激活了成年小鼠视皮层的可塑性。该项结果发表在Neuropharmacology, 128:207-220，2017。

6，揭示了内源性大麻醇及其受体 ( Endocannabinoids and receptors ) 在视皮层中间抑制神经元（GABAergic interneuron）发育成熟过程中的重要作用。视皮层的抑制神经元的突触在其靶细胞上的分枝和增殖需要内源性大麻醇及其受体的参与。视皮层不同片层间的抑制神经元对大麻醇及其受体的敏感性不同，显示出不同片层上的抑制神经突触发育可塑性（Jiang et al. Neuron 2010; Jiang et al. J. Neurosci. 2010）。

7，剥夺视觉经验不仅仅影响视皮层的活动，同时增强体感皮层和听皮层神经元的电活动，呈现所谓的皮层领域间跨模态突触可塑性。一种感觉经验丧失可以同时影响多个皮层区域的神经细胞活动。从细胞学的角度阐明了盲人具有很强的触觉和听觉的基本神经机制（Goel and Jiang et al. Nat. Neurosci. 200）。

在研科研项目：

1、广东省重点领域研发计划项目: 2018B030335001, 自闭症的诊疗方法研究。,

2、国家自然科学基金面上项目 32071101/C1105 下丘脑投射到视皮层的食欲素能神经纤维的功能研究。

3，国家自然科学基金面上项目, 81870869/H0903, 神经病理性疼痛引起视觉皮层神经可塑性改变及其机理的研究。

4，广州市科技计划项目重点领域研发计划，202007030001 放射性脑损伤的诊治和康复的关键技术研究。

5，眼科国家重点实验室开放课题：2020KF03 早期应急改变成年动物视皮层可塑性的机理研究。  

著作

学术论文（精选）：

1.Yueqin Liu; Sitong Li; Xinxin Zhang; Laijian Wang; Ziming Li; Wei Wu; Xinya Qin; Jiangning Zhou; Chenchen Ma; Wei Meng; Xi Kuang; Fei Yin; Qianhui Xia; Bin Jiang*; Yupeng Yang（2022）Corticotropin releasing factor neurons in the visual cortex mediate long-term changes in visual function induced by early adversity. Neurobiology of Stress. 2022.100504. eCollection

2.Xuanyue Ma; Liuren Li; Ziming Li; Zhengyi Huang; Yaorong Yang; Peng Liu; Daji Guo; Yueyao Li; Tianying Wu; Ruixiang Luo; Junyu Xu; Wen-Cai Ye; Bin Jiang*; Lei Shi (2022) eEF2 in the prefrontal cortex promotes excitatory synaptic transmission and social novelty behavior. EMBO Reports, 2022 Oct 6;23(10):e54543

3.Bailing Chen; Laijian Wang; Xuejun Li; Zhe Shi; Juan Duan; Ji-An Wei; Cunzheng Li; Chaoqin Pang; Diyang Wang; Kejiao Zhang; Hao Chen; Wanying Na; Li Zhang; Kwok-Fai So; Libing Zhou; Bin Jiang*; Ti-Fei Yuan; Yibo Qu (2022) Celsr2 regulates NMDA receptors and dendritic homeostasis in dorsal CA1 to enable social memory. Molecular Psychiatry, 2022 Jul 4. doi: 10.1038/s41380-022-01664-x Online ahead of print.

4.Yang Y, Xu HY, Deng QW, Wu GH, Zeng X, Jin H, Wang LJ, Lai BQ, Li G, Ma YH, Jiang B, Ruan JW, Wang YQ, Ding Y, Zeng YS（2021）. Electroacupuncture facilitates the integration of a grafted TrkC-modified MSC-derived neural network into transected spinal cord in rats via increasing neurotrophin-3. CNS Neuroscience & Therapeutics27(7):776-791

5.Li G, Zhang B, Sun JH, Shi LY, Huang MY, Huang LJ, Lin ZJ, Lin QY, Lai BQ, Ma YH, Jiang B, Ding Y, Zhang HB, Li MX, Zhu P, Wang YQ, Zeng X, Zeng YS（2021） An NT-3-releasing bioscaffold supports the formation of TrkC-modified neural stem cell-derived neural network tissue with efficacy in repairing spinal cord injury. Bioactive Materials 6 (11):3766-3781

6.Yubi Lin, Jiading Qin ,Yuhui Shen, Jiana Huang, Zuoquan Zhang, ZhiLing Zhu, Huifang Lu, Yin Huang ,Yuelan Yin , Ani Wang, Lizi Jin, Zhenyu Hu,* Xiufang Lin* and Bin Jiang*  (2021) Identification of rare heterozygous linkage R965C-R1309H mutations in the pore-forming region of SCN5A gene associated with complex arrhythmia. Mol Genet Genomic Med. e1613

7.Xu HY, Yang Yang, Deng Qing-Wen, Zhang Bao-Bao, Ruan Jing-Wen, Jin Hui, Wang Jun-Hua, Ren Jiale, Jiang Bin, Sun Jia-Hui, Zeng Yuan-Shan, Ding Ying（2021）. Governor Vessel electro-acupuncture promotes the intrinsic growth ability of spinal neurons through activating CGRP/αCaMKII/NT-3 pathway after spinal cord injury. J Neurotrauma 38(6):734-745

8.Daji Guo, Yinghui Peng, Laijian Wang, Xiaoyu Sun, Xiaojun Wang, Chunmei Liang, Shengnan Li, Junyu Xu, Wen-Cai Ye, Bin Jiang*, Lei Shi*（2019）Autism-like social deficit generated by Dock4 deficiency is rescued by restoration of Rac1 activity and NMDA receptor function. Molecular Psychaitry. 26:1505–1519 

9.Lai BQ, Che MT, Feng B, Bai YR, Li G, Ma YH, Wang LJ, Huang MY, Wang YQ, Jiang B, Ding Y, Zeng X, Zeng YS （2019）Tissue-engineered neural network graft relays excitatory signal in the completely transected canine spinal cord. Advanced Science, 6(22):1901240 (1 of 19) (IF: 15.804, citation 9)

10.Jin H, Zhang YT, Yang Y, Wen LY, Wang JH, Xu HY, Lai BQ, Feng B, Che MT, Qiu XC, Li ZL, Wang LJ, Ruan JW, Jiang B, Zeng X, Deng QW, Li G, Ding Y, Zeng YS（2019）Electroacupuncture facilitates the integration of neural stem cell-derived neural network with transected rat spinal cord. Stem Cell Reports, 2:274-289

11.Wu GH, Shi HJ, Che MT, Huang MY, Wei QS, Feng B, Ma YH, Wang LJ, Jiang B, Wang YQ, Han I, Ling EA, Zeng X, Zeng YS（2018）Recovery of paralyzed limb motor function in canine with complete spinal cord injury following implantation of MSC-derived neural network tissue. Biomaterials 181:15-34 (IF: 12.1, citation 28）

12.Lai BQ, Feng B, Che MT, Wang LJ, Cai S, Huang MY, Gu HY, Jiang B, Ling EA, Li M, Zeng X, Zeng YS（2018）A modular assembly of spinal cord-like tissue endows targeted tissue repair in the transected spinal cord. Advanced Science 5(9):1800261(1 of 14) 

13.Zou JL, Liu S, Sun JH, Yang WH, Xu YW, Rao ZL, Jiang B, Zhu QT, Liu XL, Wu JL, Chang C, Mao HQ, Ling EA, Quan DP, Zeng YS（2018）Peripheral nerve-derived matrix hydrogel promotes remyelination and inhibits synapse formation. Advanced Functional Materials. 28(13):1705739 (1 of 12)

14.Xiaoxiu Tie, Shuo Li, Yilin Feng, Biqin Lai, Sheng Liu* , Bin Jiang*（2018）Distinct Roles of NMDAR and mGluR5 in Light Exposure Reversal of Feedforward Synaptic Strength in V1 of Juvenile Mice after Binocular Vision Deprivation. Neuroscience. 384:131-138 (IF:3.879, citation 1)

15.Yue Li，LaijianWang， Xinxin Zhang， Mengyao Huang，Sitong Li，Xinxing Wang，Lin Chen, Bin Jiang* and Yupeng Yang*(2017) Inhibition of Cdk5 rejuvenates inhibitory circuits and restores experience-dependent plasticity in adult visual cortex. Neuropharmacology. 128:207-220 （IF：5.77, citation 7）

16.Shuo Li, Laijian Wang, Xiaoxiu Tie，Kazuhiro Sohya, Xian Lin, Alfredo Kirkwood and Bin Jiang*（2017） Brief novel visual experience fundamentally changes synaptic plasticity in the mouse visual cortex. Journal of Neuroscience. 37(39):9353-9360

17.Meige Zheng, Luyan Jiao, Xiaolu Tang, Xianhong Xiang, Xiaomei Wan, Yan Yan, Xingjian Li, Guofeng Zhang, Yonglin Li, Bin Jiang, Huaibin Cai and Xian Lin (2017) Tau haploinsufficiency causes prenatal loss of dopaminergic neurons in the ventral tegmental area and reduction of transcription factor orthodenticle homeobox 2 expression. FASEB J. 31:3349-3358 (IF:5.56, citation 7)

18.Wenjuan Sun, Laijian Wang , Shuo Li, Xiaoxiu Tie and Bin Jiang*（2015) Layer-specific endocannabinoid-mediated long-term depression of GABAergic neurotransmission onto principal neurons in mouse visual cortex. European Journal of Neuroscience 42:1952-1965 （IF.3.37, citation 10）

19.Masoumeh Arami, Kazuhiro Sohya, Abdolrahman Sarihi, Bin Jiang, Yuchio Yanagawa, and Tadaharu Tsumoto (2013) Reciprocal homo- and hetero-synaptic long-term plasticity of cortico-geniculate projection neurons in layer VI of the mouse visual cortex. Journal of Neuroscience 33:7787-7798. (IF. 7.0, citation 13)

20.Abdolrahman Sarihi, Javad Mirnajafi-Zadeh, Bin Jiang, Kazuhiro Sohya, Mir-Shahram Safari, Masoumeh Kourosh Arami, Yuchio Yanagawa and Tadaharu Tsumoto (2012) Cell Type-Specific, Presynaptic LTP of inhibitory synapses on fast-spiking GABAergic neurons in the mouse visual cortex. Journal of Neuroscience 32:13100-13110. (IF. 6.993, citation 13)

21.Bin Jiang*, Kazuhiro Sohya, Abdolrahman Sarihi, Yuchio Yanagawa, Tadaharu Tsumoto* (2010) Laminar-specific maturation of GABAergic transmission and susceptibility to visual deprivation are related to endocannabinoid sensitivity in mouse visual cortex. Journal of Neuroscience 30: 14261-14272. (Equally corresponding authors) 

22.Bin Jiang, Shiyong Huang, Roberto de Pasquale, Daniel Millman, Lihua Song, Hey-Kyoung Lee, Tadaharu Tsumoto, Alfredo Kirkwood (2010) The maturation of GABAergic transmission in visual cortex requires endocannabinoid-mediated LTD of inhibitory inputs during a critical period. Neuron 66: 248-259.

23.Toshimitsu Suzuki, Hiroyuki Miyamoto, Takashi Nakahari, Ikuyo Inoue, Takahiro Suemoto, Bin Jiang, Yuki Hirota, Shigeyoshi Itohara, Takaomi C. Saido, Tadaharu Tsumoto, Kazunobu Sawamoto, Takao K. Hensch，Antonio V. Delgado-Escueta, Kazuhiro Yamakawa (2009) Efhc1/myoclonin1 deficiency causes spontaneous myoclonus and increased seizure susceptibility. Human Molecular Genetics 18: 1099-1109. (IF.7.4, citation 56).

24.Abdolrahman Sarihi, Bin Jiang, Alireza Komaki, Kazuhiro Sohya, Yuchio Yanagawa, Tadaharu Tsumoto (2008) Metabotropic glutamate receptor type 5-dependent long-term potentiation of excitatory synapses on fast-spiking GABAergic neurons in mouse visual cortex. Journal of Neuroscience 28: 1224-1235. 

25.Bin Jiang, Mario Treviño, Alfredo Kirkwood (2007) Sequential development of long-term potentiation and depression in different layers of the mouse visual cortex. Journal of Neuroscience 27: 9648-9652. (IF.7.5, citation 89)

26.Anubhuthi Geol*, Bin Jiang*, Linda W. Xu, Lihua Song, Alfredo Kirwood, Hey-Kyoung Lee (2006) Cross-modal regulation of synaptic AMPA receptors in primary sensory cortices by visual experience. Nature Neuroscience 9: 1001-1003. (Equally contributing authors) (共同第一作者，IF.25.875, citation, 147)

27.Se-Young Choi, Jeff Chang, Bin Jiang, Geun-Hee Seol, Sun-Seek Min, Jung-Soo Han, Hee-Sup Shin, Michela Gallagher, Alfredo Kirkwood (2005) Multiple receptors coupled to phospholipase C gate long-term depression in visual cortex. Journal of Neuroscience 25: 11433-11443. (IF.7.45, citation 81)

28.Bin Jiang, Z. Josh Huang, Bernardo Morales, Alfredo Kirkwood (2005) Maturation of GABAergic transmission and the timing of plasticity in visual cortex. Brain Research Reviews 50: 126-133. (IF.8.78, citation 80)

29.Yukio Akaneya, Bin Jiang, Tadaharu Tsumoto (2005) RNAi-induced gene silencing by local electroporation in targeting brain region. Journal of Neurophysiology 93: 594-602. (IF. 3.88, citation 99)

30.Bin Jiang, Akihiko Kitamura, Hiroki Yasuda, Kazuhiro Sohya, Atsushi Maruyama, Yuchio Yanagawa, Kunihiko Obata, Tadaharu Tsumoto (2004) Brain-derived neurotrophic factor acutely depresses excitatory synaptic transmission to GABAergic neurons in visual cortical slices. European Journal of Neuroscience 20: 709-718. (IF.3.89, citation 28)

31.Bin Jiang, Yukoi Akaneya, Yoshio Hata, Tadaharu Tsumoto (2003) Long-term depression is not induced by low frequency stimulation in visual cortex in vivo: Possible preventing role of endogenous brain-derived neurotrophic factor. Journal of Neuroscience 23: 3761-3770. (IF.7.5, Citation 46)

32.Bin Jiang, Yukoi Akaneya, Minoru Ohshima, Satoshi Ichisaka, Yoshio Hata, Tadaharu Tsumoto (2001) Brain-derived neurotrophic factor induces long-lasting potentiation of synaptic transmission in visual cortex in vivo in young rats, but does not in the adult. European Journal of Neuroscience 14: 1219-1228. (IF.3.98, Citation 41。