周忠卫

职位

副教授

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周忠卫

个人简介

周忠卫博士,现任中山大学医学院副教授,硕士生导师。2002年和2005年先后于兰州大学生命科学学院获本科和硕士学位;于2013年取得德国耶拿大学博士学位,师从欧洲科学院院士Zhao-Qi Wang 教授。2005年至2008年,在中国科学院遗传与发育生物学研究所从事研究实习员工作;博士毕业后,在德国莱布尼兹研究院衰老研究所从事博士后工作。2017年获聘中山大学百人计划引进人才,医学院独立PI、学术带头人。

细胞内DNA时刻面临由内源和外部因素引发的损伤。DNA损伤激活DNA损伤应答(DNA damage responseDDR)信号通路。DDR通路调控包括细胞周期、损伤修复、基因转录、凋亡或自噬等过程,以维持基因组稳定性、组织稳态并防止疾病如癌症的发生。DDR通路的缺陷或关键分子的突变,引发各种染色体不稳定性综合征。肿瘤易感、免疫缺陷、神经缺陷(包括小头症和神经退行性病变)及早衰是这些综合征的主要症状。目前主要研究DNA损伤应答分子调控神经发育及关联疾病的作用机制。相关研究成果已发表在Nature Cell Biology, Cell Stem Cell, Cell Research, Molecular Cell, Nature Communications, EMBO J, Cell Report, PLOS Genetics, DNA Repair等多种国际学术杂志和期刊上。发表的科研论文累计影响因子超过130分。

研究方向: 基因组稳定性维持与神经发育

研究的主要内容包括1DDR分子与神经干细胞命运决定;2)小头症(Microcephaly) 的致病机理;3DNA损伤应答关键分子的经典及非经典功能在神经退行性病变中的作用机制。

本实验室长期招收具有基础医学或生物学背景的博士后及专职科研人员,诚挚欢迎加盟!

邮箱:Zhouzhw6@mail.sysu.edu.cn

著作

1Liu X, Zong W, Li T, Wang Y, Xu X,  Zhou ZW*(通讯作者) , Wang ZQ*.The E3 ubiquitin ligase APC/CCdh1 degrades MCPH1 after MCPH1-bTrCP2-Cdc25A-mediated mitotic entry to ensure neurogenesis. EMBO J. Doi: 10.15252/embj.201694443  (in press).

2. Salah F, Ebbinghaus M, Muley V, Zhou Z, Al-Saadi K, Pacyna-Gengelbach M, et al. Tumor suppression in mice lacking GABARAP, an Atg8/LC3 family member implicated in autophagy, is associated with alterations in cytokine secretion and cell death. Cell death & disease. 2016;7(4):e2205.

3.Liu X, Zhou ZW, Wang ZQ. The DNA damage response molecule MCPH1 in brain development and beyond.Acta BiochimBiophys Sin. 2016;48(7):678-85.

4.Li T, Zhou ZW, Ju Z, Wang ZQ. DNA Damage Response in Hematopoietic Stem Cell Ageing.Genomics Proteomics Bioinformatics. 2016;14(3):147-54.

5.Hoa NN, Shimizu T, Zhou ZW, Wang ZQ, Deshpande RA, Paull TT, et al. Mre11 Is Essential for the Removal of Lethal Topoisomerase 2 Covalent Cleavage Complexes. Molecular cell. 2016;64(3):580-92.

6.Tapias A, Zhou Z-W, Shi Y, Chong Z, Wang P, Groth M, et al. Trrap-dependent histone acetylation specifically regulates cell-cycle gene transcription to control neural progenitor fate decisions. Cell stem cell. 2014;14(5):632-43.

7.Bruhn C, Zhou Z-W, Ai H, Wang Z-Q. The essential function of the MRN complex in the resolution of endogenous replication intermediates. Cell reports. 2014;6(1):182-95.

8.Zhou Z-W, Tapias A, Bruhn C, Gruber R, Sukchev M, Wang Z-Q. DNA damage response in microcephaly development of MCPH1 mouse model. DNA repair. 2013;12(8):645-55.

9.Zhou Z-W, Liu C, Li T-L, Bruhn C, Krueger A, Min W, et al. An essential function for the ATR-activation-domain (AAD) of TopBP1 in mouse development and cellular senescence.PLoS genetics. 2013;9(8):e1003702.

10.Min W, Bruhn C, Grigaravicius P, Zhou ZW, Li F, Kruger A, et al. Poly(ADP-ribose) binding to Chk1 at stalled replication forks is required for S-phase checkpoint activation. Nature communications. 2013;4:2993.

11.Zhou Z, Bruhn C, Wang Z-Q. Differential function of NBS1 and ATR in neurogenesis.DNA repair. 2012;11(2):210-21.

12.Gruber R, Zhou Z, Sukchev M, Joerss T, Frappart P-O, Wang Z-Q. MCPH1 regulates the neuroprogenitor division mode by coupling the centrosomal cycle with mitotic entry through the Chk1-Cdc25 pathway. Nature cell biology. 2011;13(11):1325-34.

13.Zhou Z, Sun X, Zou Z, Sun L, Zhang T, Guo S, et al. PRMT5 regulates Golgi apparatus structure through methylation of the golgin GM130. Cell research. 2010;20(9):1023-33.

14.Liu Z, Zhou Z, Chen G, Bao S. A putative transcriptional elongation factor hIws1 is essential for mammalian cell proliferation. Biochemical and biophysical research communications. 2007;353(1):47-53.

15.Hou X, Wang Y, Zhou Z, Bao S, Lin Y, Gong W. Crystal structure of SAM-dependent O-methyltransferase from pathogenic bacterium Leptospirainterrogans. Journal of structural biology. 2007;159(3):523-8.

研究方向

基因组稳定性维持与神经发育