个人简介：
高蔓蔓博士，中山大学医学院人体解剖学教研室教学型副教授。长期从事骨软骨发育、退变与再生机理相关研究，包括阐释生长板软骨细胞肥大化的演变规律及结构基础、关节软骨内源性再生的细胞生物学机制及转化应用、生物力学引导骨软骨再生修复的关键调控机理及转化研究等。目前已经以第一或通讯作者（含共同）在Bioactive Materials, Journal of Materials Science & Technology, International Journal of Surgery, iScience等期刊发表SCI论文23篇；主持国家自然科学基金青年项目1项，深圳市科创委面上项目1项；参与骨软骨退变与再生相关项目多项，包括国家自然科学基金重点项目1项、区域联合重点项目1项、瑞士AOCMF国际合作项目1项（380万人民币，第二参与人）以及面上项目多项；获得国家发明专利授权2项。
研究领域：
骨软骨发育、退变与再生
联系方式：
gaomm5@mail.sysu.edu.cn, gaomanm@mail2.sysu.edu.cn
工作经历：
2026.03 - 至今 中山大学医学院，解剖学教研室，副教授
2024.09 – 2025.12 福州市第二总医院 骨科研究中心，副研究员
2020.11 - 2024.02 深圳大学/深圳市第二人民医院， 博士后
2018.07 - 2020.08 中山大学 附属第一医院脊柱外科，博士后
教育经历：
2015.12 - 2017.12 约翰霍普金斯大学，医学院，联合培养博士研究生
2012.09 - 2018.06 中山大学，附属第一医院脊柱外科，硕-博连读
2007.09 - 2012.06 中山大学，中山医学院临床医学系
科研项目：
1. 国家自然科学基金 青年科学基金，2020-2022，结题
2. 深圳市科创委 面上项目，2022-2025，主持
3. 瑞士AOCMF国际合作项目，2023-2027，核心参与人（排名第2）
已发表的科研文章
（一）第一作者和通讯作者文章
1.Li J, Tong K, Zhou J, Li S, He Z, Wang F, Chen H, Li H, Cheng G, Li J, Zhou Z, Gao M（最后通讯）. Integrating bulk and single-cell transcriptome profiling to uncover diagnostic biomarkers and regulatory mechanisms of oxidative stress in spinal cord injury. Neural Regeneration Research. 2025 Jan 13;9900:10.4103.
2.Li J, Li J, Li X, Wang W, Ding Y, Zhou J, Wang W, Xi Y, Gou R, Liu S, Zhou Z, Gao M（最后通讯）. Identification of coagulation diagnostic biomarkers related to the severity of spinal cord injury. International Immunopharmacology. 2024 Aug 20;137:112505.
3.Li J, Liu X, Wang J, Wang F, Zhu Z, Tang T, Wang J, Zhou Z, Gao M（最后通讯）, Liu S. Identification of immunodiagnostic blood biomarkers associated with spinal cord injury severity. Front Immunol. 2023 Mar 29;14:1101564.
4.Gao M (第一作者), Liu X, Guo P, Wang J, Li J, Wang W, Stoddart MJ, Grad S, Li Z, Wu H, Li B, He Z, Zhou G, Liu S, Zhu W, Chen D, Zou X, Zhou Z. Deciphering postnatal limb development at single-cell resolution. iScience. 2022 Dec 13;26(1):105808.
5.Wang Q, Wang W, Zhang P, Zhou Z, Li T, Li J, Canavese F, Gao M（最后通讯）. A Simplified Method for RNA Isolation from Biofabricating Hydroxyapatite Scaffolds and Identification of Appropriate Reference Genes. Journal of Medical and Biological Engineering. 2022 Aug 11;42(5):713-21.
6.Gao M (第一作者), Guo P, Liu X, Zhang P, He Z, Wen L, Liu S, Zhou Z, Zhu W. Systematic study of single-cell isolation from musculoskeletal tissues for single-sell sequencing. BMC Molecular and Cell Biology. 2022 Jul 26;23(1):32.
7.Gao M (第一作者), Wang J, Jiang L, Pan X, Canavese F, Li Y, Wang W, Zhou Z, Zhu W. Magnetic resonance imaging R2* sequences can better detect microstructural cartilage changes than T2 mapping in cynomolgus monkeys with limited knee kinematics: preliminary imaging findings. BMC Musculoskeletal Disorders. 2022 Sep 17;23(1):870.
8.Zhang F, Liu X, Li B, Li Z, Grad S, Chen D, Gao M（最后通讯）, Liu S. The effect of hyaluronic acid on nucleus pulposus extracellular matrix production through hypoxia-inducible factor-1α transcriptional activation of CD44 under hypoxia. Eur Cell Mater. 2021 Feb 3;41:142-52.
9.Gao M (第一作者), Su Q, Liang T, Ma J, Liang T, Stoddart J, Richards G, Zhou Z, Zou X. Transcriptional activation of ENPP1 by osterix in osteoblasts and osteocytes. Eur Cell Mater. 2018 Jul 25;36:1-14.
（二）共同第一作者和共同通讯作者文章
10. Wang J, Guo L, Li J, Cao X, Du W, Zhou J, Li H, Li J, Zhu Z, Tang T, Li X, Zhou Z, Liu Z, Xi Y, Gao M（共同通讯）. Cross species reproducibility of MRI radiomics features enables intervertebral disc degeneration assessment in experimental monkeys. Sci Rep 15, 45571 (2025). https://doi.org/10.1038/s41598-025-29167-z
11. Li X, Wu H, Zhang Z, Zhu J, Wu L, Lin W, Chen Y, Zhou J, Gao M（共同通讯）, Chen S. Association between frailty index and hip fracture among Chinese middle- and old-aged adults in different glycemic status: a prospective study from the China Health and Retirement Longitudinal Study (CHARLS). Int J Surg. 2026 Jan 13. doi: 10.1097/JS9.0000000000004639.
12.Hu H, Liu X, Chen J, Cui S, Yi H, Wang G, Wang R, Zheng T, Wan B, Zhou Z, Wan Y, Gao M（共同通讯）, Chen D, Zou X. Regulation of hypoxic stress and oxidative stress in bone grafting: Current trends and future perspectives. Journal of Materials Science & Technology. 2023 Sep 10;157:144-53.
13.Zhou Z, Wang W, Wang J, 11. Wang H, Xia Y, Zhang W, Lai Y, Lin X, Huang Y, Zou X, Stoddart MJ, Li Z, Tian W, Liu S, Wu X, Gao M（共同通讯）, Li J, Yang L, Chen D. Function-oriented design: A novel strategy for advanced biomedical materials. Journal of Materials Science & Technology. 2023 May 10;145:197-209.
14.Guo P, Liu X, Zhang P, He Z, Li Z, Alini M, Richards RG, Grad S, Stoddart MJ, Zhou G, Zou X, Chan D, Tian W, Chen D, Gao M（共同通讯）, Zhou Z, Liu S. A single-cell transcriptome of mesenchymal stromal cells to fabricate bioactive hydroxyapatite materials for bone regeneration. Bioactive Materials. 2022;9:281-98.
15.Chen S, Gao M（共同第一）, Zhou Z, Liang J, Gong M, Dai X, Liang T, Ye J, Wu G, Zou L, Wang Y, Zou X. Opposite Regulation of Chondrogenesis and Angiogenesis in Cartilage Repair ECM Materials under Hypoxia. Journal of Materials Science & Technology. 2016 Sep 1;32(9):978-85.
16. Zhu Y, Lu Y, Zhou C, Tong G, Gao M（共同第一）, Zhan Y, Wang Y, Liang R, Li Y, Gao T, Wang L, Zhang M, Cheng J, Gong J, Wang J, Zhang W, Qi J, Cui M, Zhu L, Xiao F, Zhu L, Xu Y, Zheng Z, Zhou Z, Cheng Z, Hong P. Association of neutralizing breadth against SARS-CoV-2 with inoculation orders of heterologous prime-boost vaccines. Med. 2022;3(8):568-78.e3.
17.He Z, Zhu Z, Tang T, Wang F, Guo P, Li J, Tung NTC, Liang Q, Liu S, Gao M（共同通讯）, Liu X, Zhou Z. Enpp1 mutations promote upregulation of hedgehog signaling in heterotopic ossification with aging. Journal of Bone and Mineral Metabolism. 2024 Aug 30;42(6):681-98.
18.Zhou J, Wang J, Li J, Zhu Z, He Z, Li J, Tang T, Chen H, Du Y, Li Z, Gao M（共同通讯）, Zhou Z, Xi Y. Repetitive strikes loading organ culture model to investigate the biological and biomechanical responses of the intervertebral disc. JOR Spine. 2024 Jan 19;7(1):e1314.
19.Wang F, Chen H, He Z, Li J, Zhu Z, Tang T, Li J, Zhou J, Tan Q, Li Z, Gao M（共同通讯）, Zhou Z, Liu S. Cellular Response To Short-Time Mechanical Stimuli: Mediating Ca2 Influx via Piezo1. European Cells and Materials. 2024 Jul;48:1-16.
20.Li J, Liu X, Wu H, Guo P, Li B, Wang J, Tian W, Chen D, Gao M（共同通讯）, Zhou Z, Liu S. Identification of hub genes related to the innate immune response activated during spinal cord injury. FEBS Open Bio. 2022 Sep 1;12(10):1839-56.
21.Wang J, Zhu P, Pan X, Yang J, Wang S, Wang W, Li B, Zhu Z, Tang T, Chen D, Gao M（共同通讯）, Zhou Z. Correlation between motor behavior and age-related intervertebral disc degeneration in cynomolgus monkeys. JOR SPINE. 2022 Jan 1;5(1):e1183.
22.Wen L, Gao M（共同第一）, He Z, Guo P, Liu Z, Zhang P, Zhang F, Chen D, Zhou G, Zhou Z. Noggin, an inhibitor of bone morphogenetic protein signaling, antagonizes TGF-β1 in a mouse model of osteoarthritis. Biochemical and Biophysical Research Communications. 2021 Sep 17;570:199-205.
23.Zhou Z, Gao M（共同第一）, Wei F, Liang J, Deng W, Dai X, Zhou G, Zou X. Shock absorbing function study on denucleated intervertebral disc with or without hydrogel injection through static and dynamic biomechanical tests in vitro. Biomed Res Int. 2014 Jun 22;2014:461724.
