简介
中山大学百人计划，副研究员，博士生导师。美国俄克拉荷马大学病理学博士，加州大学圣地亚哥分校博士后。课题组主要研究方向为蛋白质磷酸化和儿童恶性血液肿瘤。以第一或通讯作者在Blood、Journal of Hematology and Oncology、Oncogene、BMC Medicine等高水平期刊发表论文20余篇，包括ESI高被引/热点论文1篇，总引用超1500次。研究团队于2020-2023连续四年在美国血液学年会上取得杰出摘要奖。主持科研项目包括国自然面上/青年基金、广东省基础与应用基础研究基金、深圳市科创委面上项目等9项。
发表论文/著作
1. Chen, Yun#; Chen, Liguang#; Yu, Jian; Ghia, Emanuela M; Choi, Michael Y; Zhang, Ling; Zhang, Suping; Sanchez Lopez, Elsa; Widhopf, George F , II; Messer, Karen; Rassenti, Laura Z; Jamieson, Catriona; Kipps, Thomas J*; Cirmtuzumab blocks Wnt5a/ROR1 stimulation of NF-kappa B to repress autocrine STAT3 activation in chronic lymphocytic leukemia, Blood, 2019, 134(13): 1084-1094.
2. Dengyang Zhang*, Chunxiao He*, Yao Guo*, Jianfeng Li, Bo Li, Yuming Zhao, Liuting Yu, Zhiguang Chang, Hanzhong Pei, Ming Yang, Na Li, Qi Zhang, Yulong He, Yihang Pan, Zhizhuang Joe Zhao#, Changhua Zhang#, Yun Chen#; Efficacy of SCF drug conjugate targeting c-KIT in gastrointestinal stromal tumor, BMC Medicine, 2022, 20:257.
3. Yuming Zhao#, Chunxiao He#, Dengyang Zhang#, Yao Guo, Zhiyong Peng, Liuting Yu, Na Li, Chun Chen*, Zhizhuang Joe Zhao*, Yun Chen*; Leukemogenic SHP2 mutations lead to erythropoietin independency of HCD-57 cells: a novel model for preclinical research of SHP2-mutant JMML, Exp Hematol Oncol, 2023, 12:20.
4. Chunxiao He#, Zhiyong Peng#, Dengyang Zhang#, Yao Guo, Tianqi Liang, Yuming Zhao, Liuting Yu, Qi Zhang, Zhiguang Chang, Yan Xiao, Na Li, Hongman Xue, Shunjie Wu, Zhizhuang Joe Zhao*, Changhua Zhang*, Yun Chen*; Sunitinib selectively targets leukemogenic signaling of mutant SHP2 in juvenile myelomonocytic leukemia. Biochem Pharmacol, 2023, 213:115588.
5. Han Zhong Pei#, Zhiyong Peng#, Xiaomei Zhuang#, Xiaobo Wang, Bo Lu, Yao Guo, Yuming Zhao, Dengyang Zhang, Yunjun Xiao, Tianshun Gao, Liuting Yu, Chunxiao He, Shunjie Wu, Suk-Hwan Baek*, Zhizhuang Joe Zhao*, Xiaojun Xu*, Yun Chen*; miR-221/222 induce instability of p53 By downregulating deubiquitinase YOD1 in acute myeloid leukemia, Cell Death Discov, 2023, 9:249.
6. Chen, Yun#; Guo, Yao; Zhao, Wanke; Ho, Wanting Tina; Fu, Xueqi; Zhao, Zhizhuang Joe*; Identification of an orally available compound with potent and broad FLT3 inhibition activity, Oncogene, 2016, 35(23): 2971-2978.
7. Chen, Yun#; Guo, Yao#; Han, Jiayu; Ho, Wanting Tina; Li, Shibo; Fu, Xueqi; Zhao, Zhizhuang Joe*; Generation and characterization of a highly effective protein substrate for analysis of FLT3 activity, Journal of Hematology & Oncology, 2012, 5: 39.
8. Guo, Yao#; Chen, Yun#; Xu, Xuesong; Fu, Xueqi*; Zhao, Zhizhuang Joe*; SU11652 Inhibits tyrosine kinase activity of FLT3 and growth of MV-4-11 cells, Journal of Hematology & Oncology, 2012, 5:72.
9. Liu, Zhuojun#; Liu, Jia#; Zhang, Tianming; Shi, Mingxia; Chen, Xiaofang; Chen, Yun*; Yu, Jian*; Destabilization of ROR1 enhances activity of Ibrutinib against chronic lymphocytic leukemia in vivo, Pharmacological Research, 2019, 151: 0-104512.
10. Yao Guo*, Hanzhong Pei*, Bo Lu*, Dengyang Zhang, Yuming Zhao, Fuqun Wu, Honghua Sun, Junbin Huang, Peng Li, Chenju Yi, Chengming Zhu, Yihang Pan, Shunjie Wu, Chun Chen#, Xiaojun Xu#, Yun Chen#; Aberrantly expressed Wnt5a in nurse-like cells drives resistance to Venetoclax in chronic lymphocytic leukemia. Cell Death Discovery, 2022;8:82.
11. Zhang, Dengyang#; Guo, Yao#; Zhao, Yuming#; Yu, Liuting; Chang, Zhiguang; Pei, Hanzhong; Huang, Junbin; Chen, Chun; Xue, Hongman; Xu, Xiaojun; Pan, Yihang; Li, Ningning; Zhu, Chengming; Zhao, Zhizhuang Joe; Yu, Jian*; Chen, Yun*; Expression of a recombinant FLT3 ligand and its emtansine conjugate as a therapeutic candidate against acute myeloid leukemia cells with FLT3 expression, Microbial Cell Factories, 2021, 20(1):67.
12. Guo, Yao#; Sun, Honghua#; Zhang, Dengyang#; Zhao, Yuming; Shi, Mingxia; Yang, Ming; Xing, Shu; Fu, Xueqi; Bin, Ting; Lu, Bo; Wu, Shunjie; Xu, Xiaojun; Xu, Xuesong; Chen, Yun*; Zhizhuang Joe Zhao*; Development of a highly sensitive method for detection of FLT3D835Y, Biomarker Research, 2020, 8(1): 0-30.
13. Chen, Yun#; Guo, Yao#; Pan, Yihang*; Zhao, Zhizhuang Joe*; Structure analysis of the receptor binding of 2019-nCoV, Biochemical and Biophysical Research Communications, 2020, 525(1): 135-140. （ESI热点论文，ESI高被引论文）
14. Lin Chen#, Weijie Zhao#, Mengxiong Li, Yazhu Yang, Chengzi Tian, Dengyang Zhang, Zhiguang Chang, Yunzhe Zhang, Zhizhuang Joe Zhao*, Yun Chen*, Lin Ma*; SHP2 participates in decidualization by activating ERK to maintain normal nuclear localization of progesterone receptor, Reproduction, 2023.
15. Yan Xiao#, Bingbing Hu#, Yao Guo, Dengyang Zhang, Yuming Zhao, Yun Chen, Na Li, Liuting Yu; "Targeting Glutamine Metabolism as an Attractive Therapeutic Strategy for Acute Myeloid Leukemia," Current Treatment Options in Oncology, 2023.
16. Zhijie Wang#, Donglin Wu#, Xiaofei Zhao#, Canlin Liu, Siming Jia, Qindi He, Fei Huang, Zitian Cheng, Tao Lu*, Yadong Chen*, Yun Chen*, Pei Yang*, Shuai Lu*; "Rational discovery of dual FLT3/HDAC inhibitors as a potential AML therapy," European Journal of Medicinal Chemistry, 2023.
