个人简介

田国宝,男,博士,教授,博士生导师,中山大学医学部学术委员会副主任委员、医学院副院长、医学教育处副处长、热带病防治研究教育部重点实验室副主任、中山大学中山医学院免疫学与微生物学系副主任。国家自然科学基金杰出青年科学基金获得者,国家自然科学基金优秀青年科学基金获得者,广东省自然科学基金杰出青年基金获得者,广东特支计划青年拔尖人才、广州市珠江科技新星,中山大学逸仙杰出学者,中山大学“百人计划”引进人才。2015年至2022年先后任中山医学院免疫学教研室党支部书记、中山医学院团委书记、中山医学院微生物学教研室党支部书记、作为中组部第九批援藏干部担任西藏民族大学医学部副主任和医学院院长。一直致力于抗生素耐药性与生物安全研究,先后在The Lancet Microbe,The Lancet Infectious Diseases,Molecular Biology and Evolution,Clinical Infectious Diseases等本领域国际顶尖和主流期刊上发表通讯作者SCI论文60余篇,参编专著5部,获省部级奖2项,以第一发明人申请专利11项(授权4项)。主持国家自然科学基金杰青项目、重点项目、国际合作研究项目、优青项目、面上项目、广东省杰出青年基金项目等10余项;主持和参与国家传染病重大专项、国家重点研发计划项目和课题10余项。The Lancet, The Lancet Infectious Diseases,Drug Resistance Updates,Emerging Infectious Diseases,Antimicrobial Agents and Chemotherapy等本领域专业杂志审稿人或编委,国家自然科学基金重大、重点、国际合作、面上/青年/地区等项目通讯和会议评审专家。

Personal Details

I am currently working as a Principal Investigator and a PhD. mentor at Sun Yat-sen University School of Medicine. I am the deputy chairman of the academic committee of the medical faculty, vice dean of the School of Medicine and deputy director of the Medical Education Office, Sun Yat-sen University, and deputy director of the Key Laboratory of Tropical Disease Control, Ministry of Education. Before joining the SYSU, I have been appointed as a postdoctoral scientist at the University of Pittsburgh School of Medicine. I had received the National Natural Science Fund for Distinguished Young Scientists Fund Program in 2023, and the National Natural Science Fund for Excellent Young Scientists Fund Program in 2017. My research area is focusing on the different mechanisms of bacterial resistance and clinical bacterial infections. In this research area, I have published over 60 articles in internationally influential journals including Lancet Infectious Diseases, Clinical Infectious Diseases, Antimicrobial Agents and Chemotherapy, Emerging Infectious Diseases, etc. I am the principal investigator on 20 major project grants funded by regional/state bodies in China to investigate antibiotic resistance bacteria with total budget ~40,000,000 RMB. Moreover, I am a reviewer for Lancet, Lancet Infectious Diseases, Antimicrobial Agents and Chemotherapy, Emerging Infectious Diseases, Journal of Antimicrobial Chemotherapy

邮箱(Email)

tiangb@mail.sysu.edu.cn

招聘信息

常年招聘博士后,热烈欢迎有医学、生物学、药学等相关研究背景人员加入我们团队。

研究生招生学科专业

免疫学(基础医学)、微生物学(生物学)、生物与医药

研究方向

抗生素耐药性

研究兴趣

抗生素的发现是20世纪医学史上最辉煌的成就之一。然而,随着抗生素大量和无序使用,抗生素耐药问题则已成为21世纪人类不得不面对的严峻挑战。抗生素耐药问题不仅是困扰临床的一大难题,“超级耐药细菌”的不断出现更是引起公众的极大恐慌,成为全球普遍关注的公共生物安全问题。我国202010月颁布的《生物安全法》将抗微生物耐药问题列为八大主题之一。WHO统计,每年全球直接死于耐药菌感染的人数超过100万,并预测,照此趋势到2050年这一数字将达1000万人/年。我国是抗生素耐药重灾区,医院多重耐药率超过70%。鉴于抗生素耐药问题的严重性,多国政府和国际组织都相继颁布了抗击抗生素耐药问题的行动计划,以期减轻和消除抗生素耐药性的危害。团队研究兴趣主要包括:

1)    抗生素耐药机制

2)    抗生素耐药与临床细菌感染

3)    抗生素耐药性与生物安全

4)    抗生素耐药微生态

5)    新型抗菌活性分子和药物研发

代表性科研项目

1.       国家自然科学基金(国际合作研究项目)82061128001,靶向琥珀酸代谢的新抗菌药物研究,2021/01-2023/12,主持

2.       国家自然科学基金(重点项目81830103质粒介导多粘菌素耐药新机制MCR-1的传播和进化及抑制剂研究2019/01-2023/12,主持

3.       国家自然科学基金(优秀青年科学基金项目)81722030临床细菌耐药与感染2018/01-2020/12,主持

4.       广东省自然科学基金(杰出青年科学基金项目)2017A030306012,质粒介导多粘菌素耐药新机制mcr-1及其传播风险因素研究,2017/01 -2021/12,主持

5.       “广东特支计划”百千万工程青年拔尖人才2016,细菌耐药性,主持

6.       重大传染病防治国家科技重大专项 “十三五”计划课题,2017ZX103023012017/1-2020/12,结核病新型诊断产品的研发与产业化,在研,核心骨干

7.       高校基本科研业务费青年教师重点培育项目,16ykzd09,耐碳青霉稀类药物“超级细菌”的耐药传播分子机制及临床治疗,2016/01-2018/12,主持

8.       国家自然科学基金项目,81471988,新型超广谱β-内酰胺酶PME耐药传播分子机制,2015/01-2018/12,主持

9.       国家重点研发计划,2016YFC1200100输入性传染病的输入机制与播散规律2016/07-2018/12,参与(核心骨干)

10.    2018年珠海市引进高层次卫生团队(柔性),抗生素耐药与感染研究创新团队, 2019-2023,主持

11.    广东省科技发展专项,2016A020219002,动物和人源产碳青霉烯酶超级细菌的流行病学和传播机制比较研究,2016/01-2018/12,主持

12.    广州市珠江新星专项,2014J2200038,广东产新型超广谱β-内酰胺酶PME耐药传播分子机制及风险,2014/01-2016/12,主持

13.    广东省自然科学基金项目,S2013010015810,广东PME酶学功能及耐药传播分子机制,2014/10~2016/10,主持

14.    国家重大科技专项传染病专项“十二五”计划课题,2013ZX10003001,结核病新型诊断产品研发及其产业化,2013/01-2015/12,参与(核心骨干)

15.    广东省海洋经济创新发展区域示范专项项目,GDHY2012-01-001,海洋生物天然产物化合物库,2012/12-2015/12,参与

16.    国家自然科学基金项目,81201325,产CTX-M-15多重耐药E.coli ST131耐药传播分子机制研究,2013/01-2015/1,主持

17.    广东省自然科学基金项目,S2012040006856,广东地区产CTX-M-15多重耐药E.coli ST131耐药传播分子机制研究,2012/10-2014/12,主持

专利

1.       田国宝、黄曦、钟兰兰、张雪飞;一种用于快速检测细菌超广谱β-内酰胺酶耐药基因SMELAMP试剂盒及检测方法;国内专利;专利号:ZL201510349336.3(已授权,201921日);专利申请日:2015.06.23;授权公告日:2019.02.01

2.       田国宝、黄曦、钟兰兰、张雪飞;一种结核分枝杆菌katG耐药突变位点检测试剂盒;国内专利;专利号:ZL201510678805.6(已授权, 2019416日);专利申请日:2015.10.20;授权公告日:2019.04.16

3.       田国宝、柏川、冯思源、沈聪;一种MCR-1抑制剂及其在制备抑制MCR-1阳性耐药菌药物中的应用;国内专利;专利号:ZL201810494825.1(已授权, 20191011);专利申请日:2018.05.22;授权公告日:2019.10.11

4.       柏川,田国宝劳楚瑜,钟兰兰,温馨;氢化喹诺林类化合物在增强细菌对多粘菌素敏感性中的应用;国内专利;专利号:ZL201810494214.7(已授权, 20191011);专利申请日:2018.05.22;授权公告日:2019.10.11

5.       田国宝、钟兰兰;一种用于快速鉴别细菌多粘菌素耐药基因mcr具体分型的多重LAMP试剂盒和检测方法;国内专利;申请号:201910188849.9

6.       田国宝、黄曦、钟兰兰、曾昆姣、沈聪; 一种快速检测细菌多粘菌素耐药基因mcr-1LAMP引物组、试剂盒及检测方法国内专利;申请号:201710153044.1 

7.       田国宝、黄曦、钟兰兰、张雪飞;一种用于快速检测细菌超广谱β-内酰胺酶耐药基因PMELAMP试剂盒及检测方法;国内专利;申请号:201510349238.X

8.       田国宝、黄曦、钟兰兰、张雪飞;一种用于快速检测细菌AmpC酶耐药基因CMY-2LAMP试剂盒及检测方法;国内专利;申请号:201510353048.5

9.       田国宝、黄曦、钟兰兰、张雪飞;一种用于快速检测细菌金属β-内酰胺酶耐药基因IMPLAMP试剂盒及检测方法;国内专利;申请号:201510353287.0

10.    田国宝、黄曦、钟兰兰、张雪飞;一种用于快速检测细菌金属β-内酰胺酶耐药基因VIMLAMP试剂盒及检测方法;国内专利;申请号:201510353189.7

11.    田国宝,闫素君,刘岚,李静,加春秀,曾昆姣,Tetrahydroauroglaucin化合物的制备方法及应用;国内专利;申请号:CN201710807943.9.

荣誉

1.       2022年获西藏民族大学优秀党员管理干部和优秀党员称号(援藏期间)

2.       2021年获中山大学中山医学院优秀共产党员称号

3.       2021年指导学生获中山大学优秀博士学位论文奖(博士生:沈聪)

4.       2021年获四川省科学技术进步二等奖(排名第2

5.       2019年获中山大学“叶任高-李幼姬”临床医学专业优秀教师奖

6.       2018年获中山大学优秀共产党员称号

7.       2017年获国家自然科学基金优秀青年科学基金项目

8.       2016年获广东省自然科学基金杰出青年科学基金项目

9.       2016年获高校基本科研业务费青年教师重点培育项目

10.    2016年获中山大学中山医学院优秀党务工作者称号

11.    2015年获“广东特支计划”百千万工程青年拔尖人才项目

12.    2014年获广州市珠江科技新星项目

13.    2013年获广东省高等院校“千百十工程”第七批校级培养对象

14.    2012年所属“抗感染免疫”团队获第四届中国侨界贡献(创新团队)

15.    2012年获国家科技进步奖二等奖(排名第13

 

著作

代表性科研论文

1.       Feng S*, Liang W*, Li J, Chen Y, Zhou D, Liang L, Lin D, Li Y, Zhao H, Du H, Dai M, Qin LN, Bai F, Doi Y#, Zhong LL#Tian GB#. MCR-1-dependent lipid remodelling compromises the viability of Gram-negative bacteria. Emerging Microbes & Infections. 2022 Dec;11(1):1236-1249. doi: 10.1080/22221751.2022.2065934. (最后通讯作者,中科院二区,影响因子19.568)

2.       He Z, Yang Y, Li W, Ma X, Zhang C, Zhang J, Sun B#, Ding T#, Tian GB#. Comparative genomic analyses of Polymyxin-resistant Enterobacteriaceae strains from China. BMC Genomics. 2022 Jan 31;23(1):88. doi: 10.1186/s12864-022-08301-5. (最后通讯作者,中科院二区,影响因子4.547)

3.       Liang L*, Lin D*, Chen Y*, Li J*, Liang W, Zhao H, Luo W#, Tian GB#, Feng S#. Single-Fluorescence ATP Sensor Based on Fluorescence Resonance Energy Transfer Reveals Role of Antibiotic-Induced ATP Perturbation in Mycobacterial Killing. mSystems. 2022 May 26;e0020922. doi: 10.1128/msystems.00209-22. (共同通讯作者,中科院二区,影响因子7.324)

4.       Qin M*, Chen P*, Deng B*, He R, Wu Y, Yang Y, Deng W, Ding X, Yang F#, Xie C#, Yang Y#Tian GB#. The Emergence of a Multidrug-Resistant and Pathogenic ST42 Lineage of Staphylococcus haemolyticus from a Hospital in China. Microbiology Spectrum. 2022 May 17;e0234221. doi: 10.1128/spectrum.02342-21. (最后通讯作者,中科院二区,影响因子9.043)

5.       Feng S*, Wu Z*, Liang W*, Zhang X, Cai X, Li J, Liang L, Lin D, Stoesser N, Doi Y, Zhong LL, Liu Y, Xia Y, Dai M, Zhang L, Chen X#, Yang JR#Tian GB#. Prediction of Antibiotic Resistance Evolution by Growth Measurement of All Proximal Mutants of Beta-Lactamase. Molecular Biology And Evolution. 2022 May 3;39(5):msac086. doi: 10.1093/molbev/msac086. (最后通讯作者,中科院一区,影响因子8.800)

6.       Wu Y, He R, Qin M, Yang Y, Chen J, Feng Y, Liang X, Deng W, Ding X, Qin LN, Liao K#, Yang Y#Tian GB#Identification of Plasmid-Mediated Tigecycline-Resistant Gene tet(X4) in Enterobacter cloacae from Pigs in China. Microbiology Spectrum. 2022 Mar 1:e0206421. doi: 10.1128/spectrum.02064-21. (最后通讯作者,中科院二区,影响因子9.043)

7.       Wen X, Shen C, Xia J, Zhong LL, Wu Z, Ahmed MAEE, Long N, Ma F, Zhang G, Wu W, Luo J, Xia Y, Dai M, Zhang L, Liao K, Feng S, Chen C, Chen Y#, Luo W#Tian GB#Whole-Genome Sequencing Reveals the High Nosocomial Transmission and Antimicrobial Resistance of Clostridioides difficile in a Single Center in China, a Four-Year Retrospective Study. Microbiology Spectrum. 2022 Feb 23;10(1):e0132221. doi: 10.1128/spectrum.01322-21. (最后通讯作者,中科院二区,影响因子9.043)

8.       Yang Y*, Yang Y*, Ahmed MAEE*, Qin M, He R, Wu Y, Liang X, Zhong LL, Chen P, Deng B, Hassan RM, Wen W, Xu L, Huang X#, Xu L#Tian GB#Carriage of Distinct blaKPC-2 and blaOXA-48 Plasmids in a Single ST11 Hypervirulent Klebsiella pneumoniae Isolate in Egypt. BMC Genomics. 2022 Jan 8;23(1):20. doi: 10.1186/s12864-021-08214-9.(最后通讯作者,中科院二区,影响因子4.547

9.       Wu Z*, Cai X*, Zhang X, Liu Y, Tian GB, Yang JR#, Chen X#Expression Level is a Major Modifier of the Fitness Landscape of a Protein Coding Gene. Nature Ecology & Evolution. 2022 Jan;6(1):103-115. doi: 10.1038/s41559-021-01578-x. Epub 2021 Nov 18.(合作作者,中科院一区,影响因子19.100

10.    Shen C*, Zhong LL*, Zhong Z*, Doi Y, Shen J, Wang Y, Ma F, Ahmed MAEE, Zhang G, Xia Y, Chen C, Tian GB#. Prevalence ofmcr-1 in Colonized Inpatients, China, 2011-2019. Emerging Infectious Diseases. 2021 Sep;27(9):2502-2504. doi: 10.3201/eid2709.203642.(独立通讯作者,中科院一区,影响因子16.126

11.    Ahmed MAEE*, Yang Y*, Yang Y*, Yan B*, Chen G, Hassan RM, Zhong LL, Chen Y, Roberts AP, Wu Y, He R, Liang X, Qin M, Dai M, Zhang L, Li H, Yang F#, Xu L#Tian GB#. Emergence of Hypervirulent Carbapenem-Resistant Klebsiella pneumoniae Coharboring a blaNDM-1 -Carrying Virulent Plasmid and a blaKPC-2-Carrying Plasmid in an Egyptian Hospital. mSphere. 2021 May 19;6(3):e00088-21. doi: 10.1128/mSphere.00088-21.(最后通讯作者,中科院二区,影响因子5.029

12.    Feng S*, Hong Z, Zhang G, Li J, Tian GB, Zhou H, Huang X#Mycobacterium PPE31 Contributes to Host Cell Death. Frontiers in Cellular and Infection Microbiology. 2021 Apr 13;11:629836. doi: 10.3389/fcimb.2021.629836.(合作作者,中科院二区,影响因子6.073

13.    Shen C*, Ma F*, Deng S*, Zhong LL*, Ahmed MAEE, Zhang G, Yan B, Dai M, Yang F, Xia Y#Tian GB#. Prevalence, Genomic Characteristics, and Transmission Dynamics of mcr-1-Positive Salmonella enterica Typhimurium from Patients with Infectious Diarrhea.International Journal of Medical Microbiology. 2021 May;311(4):151501. doi: 10.1016/j.ijmm.2021.151501. Epub 2021 Apr 1.(最后通讯作者,中科院三区,影响因子3.658

14.    Yang Y*, Yang Y*, Chen G*, Lin M, Chen Y, He R, Galvão KN, Ahmed MAEE, Roberts AP, Wu Y, Zhong LL, Liang X, Qin M, Ding X, Deng W, Huang S, Li HY, Dai M, Chen DQ, Zhang L, Liao K, Xia Y, Tian GB#. Molecular Characterization of Carbapenem-Resistant and Virulent Plasmids in Klebsiella pneumoniae from Patients with Bloodstream Infections in China. Emerging Microbes & Infections. 2021 Dec;10(1):700-709. doi: 10.1080/22221751.2021.1906163.(独立通讯作者,中科院二区,影响因子19.568

15.    He R*, Yang Y*, Wu Y*, Zhong LL, Yang Y, Chen G, Qin M, Liang X, Ahmed MAEE, Lin M, Yan B, Xia Y, Dai M#, Chen H#, Tian GB#. Characterization of a Plasmid-Encoded Resistance-Nodulation-Division Efflux Pump in Klebsiella pneumoniae and Klebsiella quasipneumoniae from Patients in China. Antimicrobial Agents and Chemotherapy. 2021 Jan 20;65(2):e02075-20. doi: 10.1128/AAC.02075-20.(最后通讯作者,中科院二区,影响因子5.938

16.    Yang F*, Xu L*, Liang L*, Liang W*, Li J, Lin D, Dai M, Zhou D, Li Y, Chen Y, Zhao H, Tian GB, Feng S#The Involvement of Mycobacterium Type III-A CRISPR-Cas System in Oxidative Stress. Frontiers in Microbiology. 2021 Dec 9;12:774492. doi: 10.3389/fmicb.2021.774492. eCollection 2021.(合作作者,中科院二区,影响因子6.064

17.    Huang M*, Chen H*, Li C*, Liu Y*, Gan C*, Ahmed MAEE, Liu R, Shen C, Zhong R, Tian GB, Huang X, Xia J#. Rapid Fulminant Progression and Mortality Secondary to Aeromonas dhakensis Septicemia with Hepatitis B Virus Infection Following the Ingestion of Snakehead Fish in Mainland China: A Case Report. Foodborne Pathogens and Disease. 2020 Dec;17(12):743-749. doi: 10.1089/fpd.2019.2780.(合作作者,中科院三区,影响因子3.788

18.    Lin M*, Yang Y*, Yang Y*, Chen G, He R, Wu Y, Zhong LL, Ahmed MAEE, Feng S, Shen C, Wen X, Huang J, Li H, Zheng X#Tian GB#. Co-Occurrence of mcr-9 and blaNDM-1 in Enterobacter cloacae Isolated from a Patient with Bloodstream Infection. Infection and Drug Resistance. 2020 May 12;13:1397-1402. doi: 10.2147/IDR.S248342. eCollection 2020.(最后通讯作者,中科院三区,影响因子4.177

19.    Shen C*, Zhong LL, Ma F, Ahmed MAEE, Doi Y, Zhang G, Liu Y, Huang S, Li HY, Zhang L, Liao K, Xia Y, Dai M, Yan B, Tian GB#. Genomic Patterns and Characterizations of Chromosomally-Encoded mcr-1 in Escherichia coli Populations. Gut Pathogens. 2020 Nov 28;12(1):55. doi: 10.1186/s13099-020-00393-2.(独立通讯作者,中科院三区,影响因子5.324

20.    Shen C*, Zhong LL*, Yang Y*, Doi Y, Paterson DL, Stoesser N, Ma F, Ahmed MAEE, Feng S, Huang S, Li HY, Huang X, Wen X, Zhao Z, Lin M, Chen G, Liang W, Liang Y, Xia Y, Dai M, Chen DQ, Zhang L, Liao K, Tian GB#. Dynamics of mcr-1 Prevalence andmcr-1-Positive Escherichia coli After the Cessation of Colistin Use as a Feed Additive for Animals in China: a Prospective Cross-Sectional and Whole Genome Sequencing Based Molecular Epidemiological Study. The Lancet Microbe. 2020 May 01; 1(1):E34-E43.doi: 10.1016/S2666-5247(20)30005-7独立通讯作者,影响因子86.208

21.    Shen C*, Zhong LL, Doi Y, Stoesser N, Ma F, Zhao Z, Yan B, Tian GB#. Pathogenicity of mcr-1-Positive Escherichia coli from Human Infections. The Lancet Microbe. 2020 September 01; 1(5):E195. doi: 10.1016/S2666-5247(20)30119-1独立通讯作者,影响因子86.208

22.    Ahmed MAEE*, Zhong LL, Shen C, Yang Y, Doi Y, Tian GB#Colistin and Its Role in the Era of Antibiotic Resistance: An Extended Review (2000-2019). Emerging Microbes & Infections. 2020 Dec;9(1):868-885. doi: 10.1080/22221751.2020.1754133.(综述,独立通讯作者,中科院二区,影响因子19.568

23.    Feng S*, Liu Y*, Liang W, Ahmed MAEE, Zhao Z, Shen C, Roberts AP, Liang L, Liao L, Zhong Z, Guo Z, Yang Y, Wen X, Chen H#, Tian GB#Involvement of Transcription Elongation Factor GreA in Mycobacterium Viability, Antibiotic Susceptibility, and Intracellular Fitness. Frontiers in Microbiology. 2020 Mar 23;11:413. doi: 10.3389/fmicb.2020.00413. eCollection 2020. (最后通讯作者,中科院二区,影响因子6.064)

24.    Zhong LL*, Zhou Q*, Tan CY, Roberts AP, Ahmed MAEE, Chen G, Dai M, Yang F, Xia Y, Liao K, Liang Y, Yang Y, Feng S, Zheng X#, Tian GB#Multiplex Loop-Mediated Isothermal Amplification (Multi-LAMP) Assay for Rapid Detection of mcr-1 to mcr-5 in Colistin-Resistant Bacteria. Infection and Drug Resistance. 2019 Jul 2;12:1877-1887. doi: 10.2147/IDR.S210226. eCollection 2019.(最后通讯作者,中科院三区,影响因子4.177

25.    Ma F*, Shen C*, Zheng X, Liu Y, Chen H, Zhong L, Liang Y, Liao K, Xia Y#, Tian GB#, Yang Y#Identification of a Novel Plasmid Carrying mcr-4.3 in an Acinetobacter baumannii Strain in China. Antimicrobial Agents and Chemotherapy. 2019 May 24;63(6):e00133-19. doi: 10.1128/AAC.00133-19. Print 2019 Jun. (共同通讯作者,中科院二区,影响因子5.938)

26.    Liang Y*, Tu C*, Tan C*Ahmed MAEE, Dai M, Xia Y, Liu Y, Zhong LL, Shen C, Chen G, Tian GB, Liu J#, Zheng X#Antimicrobial Resistance, Virulence Genes Profiling and Molecular Relatedness of Methicillin-Resistant Staphylococcus aureus Strains Isolated from Hospitalized Patients in Guangdong Province, China. Infection and Drug Resistance. 2019 Feb 25;12:447-459. doi: 10.2147/IDR.S192611. eCollection 2019.(合作作者,中科院三区,影响因子4.177

27.    Yang F*, Shen C*, Zheng X, Liu Y, Ahmed MAEE, Zhao Z, Liao K, Shi Y, Guo X, Zhong R, Xu Z, Tian GB#Plasmid-Mediated Colistin Resistance Gene mcr-1 in Escherichia coli and Klebsiella pneumoniae Isolated from Market Retail Fruits in Guangzhou, China.Infection and Drug Resistance. 2019 Feb 11;12:385-389. doi: 10.2147/IDR.S194635. eCollection 2019.独立通讯作者,中科院三区,影响因子4.177

28.    Shen C*, Feng S*, Chen H*, Dai M*, Paterson DL, Zheng X, Wu X, Zhong LL, Liu Y, Xia Y, Ma R, Huang X, Tian GB#Transmission of mcr-1-Producing Multidrug-resistant Enterobacteriaceae in Public Transportation in Guangzhou, China. Clinical Infectious Diseases.2018 Nov 13;67(suppl_2):S217-S224. doi: 10.1093/cid/ciy661.独立通讯作者,中科院一区,影响因子20.999

29.    Feng S*, Shen C*, Chen H, Zheng X, Xia Y, Zhong LL, Huang X, Wu X#, Tian GB#Co-Production of MCR-1 and NDM-5 in Escherichia coli Isolated from a Colonization Case of Inpatient. Infection and Drug Resistance. 2018 Aug 14;11:1157-1161. doi: 10.2147/IDR.S171164. eCollection 2018.(最后通讯作者,中科院三区,影响因子4.177

30.    Xu Y*, Zhong LL*, Srinivas S, Sun J, Huang M, Paterson DL, Lei S, Lin J, Li X, Tang Z, Feng S, Shen C, Tian GB#, Feng Y#Spread of MCR-3 Colistin Resistance in China: An Epidemiological, Genomic and Mechanistic Study. EBioMedicine. 2018 Aug;34:139-157. doi: 10.1016/j.ebiom.2018.07.027.(共同通讯作者,中科院二区,影响因子11.205

31.    Shen Y*, Wu Z*, Wang Y, Zhang R, Zhou HW, Wang S, Lei L, Li M, Cai J, Tyrrell J, Tian GB, Wu C, Zhang Q, Shen J, Walsh TR#, Shen Z#Heterogeneous and Flexible Transmission of mcr-1 in Hospital-Associated Escherichia coli. mBio. 2018 Jul 3;9(4):e00943-18. doi: 10.1128/mBio.00943-18.(合作作者,中科院二区,影响因子7.786

32.    Chen YX*, Xu MY, Li HJ, Zeng KJ, Ma WZ, Tian GB, Xu J, Yang DP, Lan WJ#Diverse Secondary Metabolites from the Marine-Derived Fungus Dichotomomyces cejpii F31-1. Marine Drugs. 2017 Nov 1;15(11):339. doi: 10.3390/md15110339. (合作作者,中科院二区,影响因子6.085)

33.    Zhong LL*, Phan HTT*, Shen C, Vihta KD, Sheppard AE, Huang X, Zeng KJ, Li HY, Zhang XF, Patil S, Crook DW, Walker AS, Xing Y, Lin JL, Feng LQ, Doi Y, Xia Y, Stoesser N#, Tian GB#High Rates of Human Fecal Carriage of mcr-1-Positive Multidrug-Resistant Enterobacteriaceae Emerge in China in Association with Successful Plasmid Families. Clinical Infectious Diseases. 2018 Feb 10;66(5):676-685. doi: 10.1093/cid/cix885.(最后通讯作者,中科院一区,影响因子20.999

34.    Tian GB*, Doi Y, Shen J, Walsh TR, Wang Y, Zhang R, Huang X#MCR-1-Producing Klebsiella pneumoniae Outbreak in China.The Lancet Infectious Diseases. 2017 Jun;17(6):577. doi: 10.1016/S1473-3099(17)30266-9.(第一作者,中科院一区,影响因子71.421

35.    Wang Y*, Tian GB*, Zhang R*, Shen Y*, Tyrrell JM, Huang X, Zhou H, Lei L, Li HY, Doi Y, Fang Y, Ren H, Zhong LL, Shen Z, Zeng KJ, Wang S, Liu JH, Wu C, Walsh TR#, Shen J#Prevalence, rRisk factors, Outcomes, and Molecular Epidemiology of mcr-1-Positive Enterobacteriaceae in Patients and Healthy Adults from China: an Epidemiological and Clinical Study. The Lancet Infectious Diseases.2017 Apr;17(4):390-399. doi: 10.1016/S1473-3099(16)30527-8.(共同第一作者,中科院一区,影响因子71.421

36.    Zhong LL*, Stoesser N, Doi Y, Shen C, Huang X, Tian GB#Carriage of β-lactamase-Producing Enterobacteriaceae by Chinese Travellers. The Lancet Infectious Diseases. 2017 Feb;17(2):138-139. doi: 10.1016/S1473-3099(17)30002-6.独立通讯作者,中科院一区,影响因子71.421

37.    Gao R*, Hu Y*, Li Z*, Sun J*, Wang Q, Lin J, Ye H, Liu F, Srinivas S, Li D, Zhu B, Liu YH, Tian GB, Feng Y#Dissemination and Mechanism for the MCR-1 Colistin Resistance. PLoS Pathogens. 2016 Nov 28;12(11):e1005957. doi: 10.1371/journal.ppat.1005957.(合作作者,中科院二区,影响因子7.464)

38.    Zhong LL*, Zhang YF, Doi Y, Huang X, Zhang XF, Zeng KJ, Shen C, Patil S, Xing Y, Zou Y, Tian GB#Coproduction of MCR-1 and NDM-1 by Colistin-Resistant Escherichia coli Isolated from a Healthy Individual. Antimicrobial Agents and Chemotherapy. 2016 Dec 27;61(1):e01962-16. doi: 10.1128/AAC.01962-16. (独立通讯作者,中科院二区,影响因子5.938)

39.    Tian GB*, Jiang YQ, Huang YM, Qin Y, Feng LQ, Zhang XF, Li HY, Zhong LL, Zeng KJ, Patil S, Xing Y, Huang X#Characterization of CTX-M-140, a Variant of CTX-M-14 Extended-Spectrum β-Lactamase with Decreased Cephalosporin Hydrolytic Activity, from Cephalosporin-Resistant Proteus mirabilis. Antimicrobial Agents and Chemotherapy. 2016 Sep 23;60(10):6121-6. doi: 10.1128/AAC.00822-16. (第一作者,中科院二区,影响因子5.938)

40.    Zhang XF*, Doi Y, Huang X, Li HY, Zhong LL, Zeng KJ, Zhang YF, Patil S, Tian GB#Possible Transmission of mcr-1-HarboringEscherichia coli between Companion Animals and Human. Emerging Infectious Diseases. 2016 Sep;22(9):1679-81. doi: 10.3201/eid2209.160464. Epub 2016 Sep 15. (独立通讯作者,中科院一区,影响因子16.126)

41.    Zeng KJ*, Doi Y, Patil S, Huang X, Tian GB#Emergence of the Plasmid-Mediated mcr-1 Gene in Colistin-Resistant Enterobacter aerogenes and Enterobacter cloacae. Antimicrobial Agents and Chemotherapy. 2016 May 23;60(6):3862-3. doi: 10.1128/AAC.00345-16. (独立通讯作者,中科院二区,影响因子5.938)

42.    Liu YY*, Wang Y*, Walsh TR, Yi LX, Zhang R, Spencer J, Doi Y, Tian GB, Dong B, Huang X, Yu LF, Gu D, Ren H, Chen X, Lv L, He D, Zhou H, Liang Z, Liu JH#, Shen J#. Emergence of Plasmid-Mediated Colistin Resistance Mechanism MCR-1 in Animals and Human Beings in China: a Microbiological and Molecular Biological Study. The Lancet Infectious Diseases. 2016; 16(2):161-8. doi: 10.1016/S1473-3099(15)00424-7. (合作作者,中科院一区,影响因子71.421)

43.    Huang YM*, Zhong LL, Zhang XF, Hu HT, Li YQ, Yang XR, Feng LQ, Huang X, Tian GB#NDM-1-Producing Citrobacter freundii, Escherichia coli, and Acinetobacter baumannii Identified from a Single Patient in China. Antimicrobial Agents and Chemotherapy. 2015 Aug;59(8):5073-7. doi: 10.1128/AAC.04682-14. (独立通讯作者,中科院二区,影响因子5.938)

44.    Tian GB*, Huang YM*, Fang ZL, Qing Y, Zhang XF, Huang X#CTX-M-137, a Hybrid of CTX-M-14-Like and CTX-M-15-Like β-Lactamases Identified in an Escherichia coli Clinical Isolate. Journal of Antimicrobial Chemotherapy. 2014 Aug;69(8):2081-5. Doi: 10.1093/jac/dku126. (共同第一作者,中科院二区,影响因子5.758)

45.    Qing Y*, Cao KY*, Fang ZL, Huang YM, Zhang XF, Tian GB#, Huang X#Outbreak of PER-1 and Diversity of β-Lactamases among Ceftazidime-Resistant Pseudomonas aeruginosa Clinical Isolates. Journal of Medical Microbiology. 2014 Mar;63(Pt 3):386-392. Doi: 10.1099/jmm.0.069427-0. (共同通讯作者,中科院四区,影响因子3.196)

46.    Fang ZL*, Zhang LY*, Huang YM, Qing Y, Cao KY, Tian GB#, Huang X#OprD Mutations and Inactivation in Imipenem-ResistantPseudomonas aeruginosa Isolates from China. Infection Genetics and Evolution. 2014 Jan;21:124-8. doi: 10.1016/j.meegid.2013.10.027. (共同通讯作者,中科院三区,影响因子4.393)

47.    Zou LK*, Li LW, Pan X, Tian GB, Luo Y, Wu Q, Li B, Cheng L, Xiao JJ, Hu S, Zhou Y, Pang YJ. Molecular Characterization of β-Lactam-Resistant Escherichia coli Isolated from Fu River, China. World Journal of Microbiology & Biotechnology. 2012 May;28(5):1891-9. doi: 10.1007/s11274-011-0987-9.(合作作者,中科院三区,影响因子4.253

48.    Tian GB*, Wang HN#, Zhang AY, Zhang Y, Fan WQ, Xu CW, Zeng B, Guan ZB, Zou LK. Detection of Clinically Important β-Lactamases in Commensal Escherichia coli of Human and Swine Origin in Western China. Journal of Medical Microbiology. 2012 Feb;61(Pt 2):233-238. doi: 10.1099/jmm.0.036806-0. (第一作者,中科院四区,影响因子3.196)

 

 

教材

1.       全国高等教育医学数字化规划教材《医学微生物学》,人民军医出版社,编委(编写内容:第七章细菌耐药性)

2.       十三五高等教育医药院校规划教材《医学微生物学》,郑州大学出版社,副主编(主编杨帆、魏纪东)