周忠卫 博士
Zhouzhw6@mail.sysu.edu.cn
现任中山大学医学院副教授，博士生导师，独立课题组长，学术带头人。获兰州大学学士和硕士学位、德国耶拿大学博士学位；曾任中国科学院遗传与发育生物学研究所研究实习员、德国莱布尼兹研究院衰老研究所博士后；2017年获聘中山大学“百人计划”引进人才。
周忠卫博士课题组长期利用细胞和转基因动物模型，从事神经干细胞的命运调控与大脑皮层发育及相关疾病致病机理的研究。在Nature Cell Biology、Cell Stem Cell、Cell Research、Nucleic Acids Research、Molecular Cell、The EMBO Journal、Nature Communications等多种国际学术期刊上以第一、通讯或共同作者身份发表SCI论文30多篇，累计影响因子近400分, H-index为20；申请/授权专利4项。近5年获国家自然科学基金（主持1项）、广东省自然科学基金（主持2项，参与重大1项）、深圳市科创委基金（主持2项，参与重点1项，参与重点实验室建设1项）、中山大学百人计划启动基金等支持。
主要研究领域包括（但不限于）：
1．神经干细胞命运的表观遗传及转录后调控与大脑皮层发育；
2．神经发育障碍性疾病、发育源性神经退行性病变的致病机理；
3．生物大分子损伤累积与肿瘤和衰老；
4．铁死亡的生理与病理作用，等。
招生与招聘 本实验室欢迎具有细胞生物、生化与分子生物学、基础医学等相关背景且热爱科学研究的同学报考研究生；也非常欢迎具有生物学相关专业博士学位的研究人员加盟，共同进步与发展！有意者请发详细个人简历至Zhouzhw6@mail.sysu.edu.cn。
招生学科专业：071000 生物学-09细胞生物学，086000 生物与医药。
著作论文
主要第一及通讯作者论文(#共同作者; *共同通讯)
1. Yang Q#, Cao Q#, Yu Y, Lai X, Feng J, Li X, Jiang Y, Sun Y, Zhou ZW*, Li X*. Epigenetic and transcriptional landscapes during cerebral cortex development in a microcephaly mouse model. J Genet Genomics. 2023 Nov 1: S1673-8527(23)00223-0. doi: 10.1016/j.jgg.2023.10.006. Epub ahead of print. PMID: 37923173. (Q1)
2. Liu S, Yan S, Zhu J, Lu R, Kang C, Tang K, Zeng J, Ding M, Guo Z, Lai X, Jiang Y, Wu S, Zhou L, Sun L, Zhou ZW. Combination RSL3 Treatment Sensitizes Ferroptosis- and EGFR-Inhibition-Resistant HNSCCs to Cetuximab. Int J Mol Sci. 2022 Aug 12;23(16):9014. doi: 10.3390/ijms23169014. PMID: 36012290; PMCID: PMC9409433. (Q1)
3. Mingmei Ding#, Xiaobing Qing#, Guangyu Zhang, Carolin Baade-Büttner, Ralph Gruber, Haizhen Lu, David O Ferguson, Christian Geis, Zhao-Qi Wang* and Zhong-Wei Zhou*. The essential DDR complex MRN is dispensable for the survival and function of Purkinje neurons. Front. Aging Neurosci. 2022 Jan 28; 13:786199. doi:10.3389/fnagi.2021.786199. PMID: 35153719. (Q1)
4. Lu R, Jiang Y, Lai X, Liu S, Sun L* and Zhou ZW*. A Shortage of FTH Induces ROS and Sensitizes RAS-Proficient Neuroblastoma N2A Cells to Ferroptosis. Int J Mol Sci. 2021 Aug 18;22(16):8898. doi: 10.3390/ijms22168898. PMID: 34445601; PMCID: PMC8396332. (Q1)
5. Lu R, Zhang H, Jiang YN, Wang ZQ, Sun L* and Zhou ZW*. Post-Translational Modification of MRE11: Its Implication in DDR and Diseases. Genes (Basel). 2021 Jul 28;12(8):1158. doi: 10.3390/genes12081158. PMID: 34440334; PMCID: PMC8392716. (Q2)
6. Zhang H, Zhou ZW*, Sun L*. Aminoacyl-tRNA synthetases in Charcot-Marie-Tooth disease: A gain or a loss? J Neurochem. 2021 May;157(3):351-369. doi: 10.1111/jnc.15249. Epub 2020 Dec 19. PMID: 33236345 (Q1)
7. Zhou ZW*, Kirtay M, Schneble N, Yakoub G, Ding M, Rüdiger T, Siniuk K, Lu R, Jiang YN, Li TL, Kaether C, Barzilai A, Wang ZQ*. NBS1 interacts with Notch signaling in neuronal homeostasis. Nucleic Acids Res. 2020 Nov 4;48(19):10924-10939. doi: 10.1093/nar/gkaa716. PMID: 33010171; PMCID: PMC7641754. (Q1)
8. Liu X, Zong W, Li T, Wang Y, Xu X, Zhou ZW* and Wang ZQ*. The E3 ubiquitin ligase APC/CCdh1degrades MCPH1 after MCPH1-βTrCP2-Cdc25A-mediated mitotic entry to ensure neurogenesis. EMBO J. 2017 Dec 15;36(24):3666-3681. doi: 10.15252/embj.201694443. Epub 2017 Nov 17. PMID: 29150431; PMCID: PMC5730889. (Q1)
9. Zhou ZW#, Liu C, Li# TL, Bruhn C, Krueger A, Min W, Wang ZQ* and,] Carr AM*. An essential function for the ATR-activation-domain (AAD) of TopBP1 in mouse development and cellular senescence. PLoS Genet. 2013;9(8):e1003702. doi: 10.1371/journal.pgen.1003702. Epub 2013 Aug 8. PMID: 23950734; PMCID: PMC3738440. (Q1)
10. Zhou ZW, Tapias A, Bruhn C, Gruber R, Sukchev M, Wang ZQ. DNA damage response in microcephaly development of MCPH1 mouse model. DNA Repair (Amst). 2013 Aug;12(8):645-55. doi: 10.1016/j.dnarep.2013.04.017. Epub 2013 May 15. PMID: 23683352. (Q1)
11. Zhou Z, Bruhn C, Wang ZQ. Differential function of NBS1 and ATR in neurogenesis. DNA Repair (Amst). 2012 Feb 1;11(2):210-21. doi: 10.1016/j.dnarep.2011.10.021. Epub 2011 Nov 9. PMID: 22078264. (Q1)
12. Zhou Z#, Sun X#, Zou Z, Sun L, Zhang T, Guo S, Wen Y, Liu L, Wang Y, Qin J, Li L, Gong W, Bao S. PRMT5 regulates Golgi apparatus structure through methylation of the golgin GM130. Cell Res., 2010;20(9):1023-33. (Q1)
主要合作论文
13. Li F, Shi Z, Cheng M, Zhou Z, Chu M, Sun L, Zhou JC. Biology and Roles in Diseases of Selenoprotein I Characterized by Ethanolamine Phosphotransferase Activity and Antioxidant Potential. J Nutr. 2023 Mar 22:S0022-3166(23)35496-8. doi: 10.1016/j.tjnut.2023.03.023. Epub ahead of print. PMID: 36963501. (Q2)
14. Sun L, Zhou XL, Zhou ZW, Cui H. Editorial: Noncanonical functions of Aminoacyl-tRNA synthetases. Front Physiol. 2023 Feb 23; 14:1165515. doi: 10.3389/fphys.2023.1165515. PMID: 36909230; PMCID: PMC9996280. (Q2)
15. Li P, Wu J, Liu S, Lu R, Jiang H, Wang N, Luo M, Guo L, Xiao J, Bu L, Liu L, Xing F, Peng H, Li C, Ma L, Zhao B, Zhou Z, Guo D. The RNA polymerase of cytoplasmically replicating Zika virus binds with chromatin DNA in nuclei and regulates host gene transcription. Proc Natl Acad Sci U S A. 2022 Dec 6;119(49):e2205013119. doi: 10.1073/pnas.2205013119. Epub 2022 Nov 29. PMID: 36442102; PMCID: PMC9894162. (Q1)
16. Li Z, Wang W, Xiao Y, Du S, Chen Z, Li B, Zhou ZW, Liu K, Gao F, Sun L. Discovery of a small-molecule inhibitor targeting the ovarian tumor domain of a novel Tamdy orthonairoviruse associated with human febrile illness. J Med Virol. 2022 Aug 24. doi: 10.1002/jmv.28089. Epub ahead of print. PMID: 36002383. (Q1)
17. Baisen Zhong, Weiyu Peng, Shan Du, Bingyi Chen, Yajuan Feng, Xinfeng Hu, Qi Lai, Shujie Liu, Zhong-Wei Zhou, Pengfei Fang, Yan Wu, Feng Gao, Huihao Zhou, Litao Sun. Oridonin Inhibits SARS-CoV-2 by Targeting Its 3C-Like Protease.Small Science,2022 Mar 13; doi.org/10.1002/smsc.202100124 (Q1)
18. Feng Y, Tang K, Lai Q, Liang J, Feng M, Zhou ZW, Cui H, Du X, Zhang H, Sun L. The Landscape of Aminoacyl-tRNA Synthetases Involved in Severe Acute Respiratory Syndrome Coronavirus 2 Infection. Front Physiol. 2022 Jan 26;12:818297. doi: 10.3389/fphys.2021.818297. PMID: 35153822; PMCID: PMC8826553. (Q1)
19. Hou P, Lin Y, Li Z, Lu R, Wang Y, Tian T, Jia P, Zhang X, Cao L, Zhou Z, Li C, Gu J, Guo D. Autophagy receptor CCDC50 tunes the STING-mediated interferon response in viral infections and autoimmune diseases. Cell Mol Immunol. 2021 Oct;18(10):2358-2371. doi: 10.1038/s41423-021-00758-w. Epub 2021 Aug 27. Erratum in: Cell Mol Immunol. 2021 Dec;18(12):2682. PMID: 34453126; PMCID: PMC8484562. (Q1)
20. Kirtay M, Sell J, Marx C, Haselmann H, Ceanga M, Zhou ZW, Rahmati V, Kirkpatrick J, Buder K, Grigaravicius P, Ori A, Geis C* and Wang ZQ*. ATR regulates neuronal activity by modulating presynaptic firing. Nat Commun. 2021 Jul 1;12(1):4067. doi: 10.1038/s41467-021-24217-2. PMID: 34210973; PMCID: PMC8249387.( Q1)
21. Nenkov M, Ma Y, Haase D, Zhou Z, Li Y, Petersen I, Lu G, Chen Y. Growth inhibitory role of the p53 activator SCH 529074 in non small cell lung cancer cells expressing mutant p53. Oncol Rep. 2020 Jun;43(6):2073-2082. doi: 10.3892/or.2020.7546. Epub 2020 Mar 17. PMID: 32186773. (Q2)
22. Mei M, Zhang R, Zhou ZW, Ying Z, Wang J, Zhang H, Zheng H, Bao S. PRMT5-mediated H4R3sme2 Confers Cell Differentiation in Pediatric B-cell Precursor Acute Lymphoblastic Leukemia. Clin Cancer Res. 2019 Apr 15;25(8):2633-2643. doi: 10.1158/1078-0432.CCR-18-2342. Epub 2019 Jan 11. PMID: 30635341. (Q1)
23. Kidiyoor GR, Li Q, Bastianello G, Bruhn C, Giovannetti I, Mohamood A, Beznoussenko GV, Mironov A, Raab M, Piel M, Restuccia U, Matafora V, Bachi A, Barozzi S, Parazzoli D, Frittoli E, Palamidessi A, Panciera T, Piccolo S, Scita G, Maiuri P, Havas KM, Zhou ZW, Kumar A, Bartek J, Wang ZQ, Foiani M. ATR is essential for preservation of cell mechanics and nuclear integrity during interstitial migration. Nat Commun. 2020 Sep 24;11(1):4828. doi: 10.1038/s41467-020-18580-9. PMID: 32973141; PMCID: PMC7518249. (Q1)
24. Hoa NN, Shimizu T, Zhou ZW, Wang ZQ, Deshpande RA, Paull TT, Akter S, Tsuda M, Furuta R, Tsutsui K, Takeda S, Sasanuma H. Mre11 Is Essential for the Removal of Lethal Topoisomerase 2 Covalent Cleavage Complexes. Mol Cell. 2016 Nov 3;64(3):580-592. doi: 10.1016/j.molcel.2016.10.011. Erratum in: Mol Cell. 2016 Dec 1;64(5):1010. PMID: 27814490. (Q1)
25. Tapias A, Zhou ZW, Shi Y, Chong Z, Wang P, Groth M, Platzer M, Huttner W, Herceg Z, Yang YG, Wang ZQ. Trrap-dependent histone acetylation specifically regulates cell-cycle gene transcription to control neural progenitor fate decisions. Cell Stem Cell. 2014 May 1;14(5):632-43. doi: 10.1016/j.stem.2014.04.001. PMID: 24792116. (Q1)
26. Bruhn C, Zhou ZW, Ai H, Wang ZQ. The essential function of the MRN complex in the resolution of endogenous replication intermediates. Cell Rep. 2014 Jan 16;6(1):182-95. doi: 10.1016/j.celrep.2013.12.018. Epub 2014 Jan 2. PMID: 24388752. (Q1)
27. Min W, Bruhn C, Grigaravicius P, Zhou ZW, Li F, Krüger A, Siddeek B, Greulich KO, Popp O, Meisezahl C, Calkhoven CF, Bürkle A, Xu X, Wang ZQ. Poly(ADP-ribose) binding to Chk1 at stalled replication forks is required for S-phase checkpoint activation. Nat Commun. 2013;4:2993. doi: 10.1038/ncomms3993. PMID: 24356582. (Q1)
28. Gruber R, Zhou Z#, Sukchev M#, Joerss T, Frappart PO, Wang ZQ. MCPH1 regulates the neuroprogenitor division mode by coupling the centrosomal cycle with mitotic entry through the Chk1-Cdc25 pathway. Nat Cell Biol. 2011 Sep 25;13(11):1325-34. doi: 10.1038/ncb2342. PMID: 21947081. (Q1)
29. Salah FS, Ebbinghaus M, Muley VY, Zhou Z, Al-Saadi KR, Pacyna-Gengelbach M, O'Sullivan GA, Betz H, König R, Wang ZQ, Bräuer R, Petersen I. Tumor suppression in mice lacking GABARAP, an Atg8/LC3 family member implicated in autophagy, is associated with alterations in cytokine secretion and cell death. Cell Death Dis. 2016 Apr 28;7(4):e2205. doi: 10.1038/cddis.2016.93. PMID: 27124579; PMCID: PMC4855672. (Q1)
30. Li T, Zhou ZW, Ju Z, Wang ZQ. DNA Damage Response in Hematopoietic Stem Cell Ageing. Genomics Proteomics Bioinformatics. 2016 Jun;14(3):147-154. doi: 10.1016/j.gpb.2016.04.002. Epub 2016 May 21. PMID: 27221660; PMCID: PMC4936660. (Q1)
31. Liu X, Zhou ZW, Wang ZQ. The DNA damage response molecule MCPH1 in brain development and beyond. Acta Biochim Biophys Sin (Shanghai). 2016 Jul;48(7):678-85. doi: 10.1093/abbs/gmw048. Epub 2016 May 19. PMID: 27197793. (Q2)
32. Hou X, Wang Y, Zhou Z, Bao S, Lin Y, Gong W. Crystal structure of SAM-dependent O-methyltransferase from pathogenic bacterium Leptospira interrogans. J Struct Biol. 2007 Sep;159(3):523-8. doi: 10.1016/j.jsb.2007.04.007. Epub 2007 Apr 30. PMID: 17561415. (Q2)
33. Liu Z, Zhou Z, Chen G, Bao S. A putative transcriptional elongation factor hIws1 is essential for mammalian cell proliferation. Biochem Biophys Res Commun. 2007 Feb 2;353(1):47-53. doi: 10.1016/j.bbrc.2006.11.133. Epub 2006 Dec 5. PMID: 17184735. (Q2)
教学及其他社会服务
担任本科生的《医学细胞生物学》、《医学细胞生物学实验》、《生物化学与分子生物学》、《分子医学实验》和研究生的《神经生物学》、《模式生物实验》等课程的教学。担任Communications Biology (IF2021=6.55), International Journal of Molecular Sciences (IF2021=6.21)，Molecular neurobiology (IF2021=5.59)，Neurotoxicity Research (IF2021=3.86)，Medical Oncology (IF2021=3.74)等期刊的审稿人；Frontiers in Physiology (IF2021=4.76)，Frontiers in Neuroscience (IF2021=5.12)等期刊的Guest Editor。
