中山大学医学院副教授，硕士研究生导师。

2007年-2011年，就读于同济大学生命科学与技术学院生物技术专业，获得学士学位。 2011年-2017年，在清华大学医学院直博，研究RCCD1及其结合蛋白JMJD5在细胞骨架微管稳定性调控以及非小细胞肺癌细胞迁移中的功能，获得理学博士学位（导师：孙方霖 教授）。2017年7月-2021年9月，入职中山大学医学院，任特聘副研究员/博士后（合作导师：郭德银 教授），从事哺乳动物胚胎干细胞的抗病毒机制、病毒与宿主相互作用机制方面的研究工作。2021年9月起，任中山大学医学院副教授。近几年来，在Cell Research、Proc. Natl. Acad. Sci. USA、Signal Transduction and Targeted Therapy、Cancer Letters、The Journal of Biological Chemistry、Virologica Sinica、Journal of Molecular Cell Biology、Cell Cycle等期刊上发表SCI论文19篇，其中第一作者/通讯作者（含共同）SCI论文9篇。

学科专业：生物化学与分子生物学、病原生物学、免疫学。

联系方式： wujy68@mail.sysu.edu.cn

研究兴趣

1.哺乳动物胚胎干细胞和早期胚胎的抗病毒机制研究。

2.寨卡病毒、新冠病毒等新发突发传染病毒的致病机制，以及病毒与宿主的相互作用机制研究

承担的科研项目

1. 国家自然科学基金面上项目，32270159，2023.1.1-2026.12.31，主持；

2. 国家自然科学基金重点项目，82230075，2023.1.1-2027.12.31，项目骨干；

3. 广东省自然科学基金面上项目，2023A1515012613，2023.1.1-202512.31，主持；

4. 深圳市基础研究专项（自然科学基金）面上项目，JCYJ20220530145608018，2022.10.28-2025.10.31，主持；

5. 深圳市高等院校稳定支持计划项目，GXWD20201231165807008-20200825183117001，2021.01-2022.12，主持；

6. 国家自然科学基金青年基金项目，31800151，2019.01-2021.12，主持；

7. 中国博士后科学基金面上基金，2018M633239，2018.01-2019.12，主持。

著作

1. Ping Li#, Junyu Wu#*, Shujie Liu, Ruiqing Lu, Hualian Jiang, Niu Wang, Manhui Luo, Liping Guo, Jingshu Xiao, Lang Bu, Lihong Liu, Fan Xing, Hong Peng, Chunmei Li, Lan Ma, Bo Zhao, Zhongwei Zhou, Deyin Guo*，The RNA polymerase of cytoplasmically replicating Zika virus binds with chromatin DNA in nuclei and regulates host gene transcription. Proc Natl Acad Sci USA. 2022 Dec 6;119(49):e2205013119. (# co-first author, * co-correspondence author)

2. Junyu Wu# *, Yongheng Zhong#, Xue Liu, Xiaoyu Lu, Weijie Zeng, Chunyan Wu, Fan Xing, Liu Cao, Fuxiang Zheng, Panpan Hou, Hong Peng, Chunmei Li, Deyin Guo*, A novel phosphorylation site in SARS-CoV-2 nucleocapsid regulates its RNA-binding capacity and phase separation in host cells., Journal of Molecular Cell Biology, 2022 Jan 18;mjac003. doi: 10.1093/jmcb/mjac003. (# co-first author, * co-correspondence author)

3. Weijie Zeng#, Fan Xing#, Yanxi Ji, Sidi Yang, Tiefeng Xu, Siyao Huang, Chunmei Li, Junyu Wu*, Liu Cao*, Deyin Guo*, Evidence of infection of human embryonic stem cells by SARS-CoV-2, Frontiers in Cellular and Infection Microbiology, 2022 May 13. doi: 10.3389/fcimb.2022.911313. (* co-correspondence author)

4. Junyu Wu #, Chunyan Wu #, Fan Xing #, Liu Cao #, Weijie Zeng, Liping Guo, Ping Li, Yongheng Zhong, Hualian Jiang, Manhui Luo, Guang Shi, Lang Bu, Yanxi Ji, Panpan Hou, Hong Peng, Junjiu Huang, Chunmei Li, Deyin Guo *, Endogenous reverse transcriptase and RNase H-mediated antiviral mechanism in embryonic stem cells, Cell Research, 2021 Jun 22;1-13. doi: 10.1038/s41422-021-00524-7. (# co-first author)

5. Fan Xing #, Jingshu Xiao #, Junyu Wu #, Jiaming Liang, Xiaoyu Lu, Liping Guo, Ping Li, Panpan Hou, Chunmei Li, Deyin Guo *, Modulating the tumor microenvironment via oncolytic virus and PI3K inhibition synergistically restores immune checkpoint therapy response in PTEN-deficient glioblastoma, Signal Transduction and Targeted Therapy, 2021, doi:10.1038/s41392-021-00609-0. (# co-first author)

6. Ping Li #, Hualian Jiang #, Hong Peng, Weijie Zeng, Yongheng Zhong, Miao He, Luyang Xie, Junhai Chen, Deyin Guo, Junyu Wu *& Chun-Mei Li *, Non-structural protein 5 of Zika virus interacts with p53 in human neural progenitor cells and induces p53-mediated apoptosis, Virologica Sinica, 2021 Jul 5. doi: 10.1007/s12250-021-00422-7. (* co-correspondence author)

7. Junyu Wu#, Zhimin He#, Da-Liang Wang, and Fang-Lin Sun, RCCD1 depletion attenuates TGF-β induced EMT by stabilizing cytoskeletal microtubule in NSCLC cells, Cancer Letters, 2017; 400, 18-29. (# co-first author)

8. Junyu Wu#, Zhimin He#, Da-Liang Wang, and Fang-Lin Sun, Depletion of JMJD5 sensitizes tumor cells to microtubule-destabilizing agents by altering microtubule stability, Cell Cycle, 2016; 15, 2980-2991. (# co-first author)

9. Zhimin He#, Junyu Wu#, Xiaonan Su#, Ye Zhang, Lixia Pan, Huimin Wei, Qiang Fang, Haitao Li, Da-Liang Wang and Fang-Lin Sun, JMJD5 (Jumonji Domain-containing 5) Associates with Spindle Microtubules and Is Required for Proper Mitosis, The Journal of Biological Chemistry, 2016; 291(9):4684-97. (# co-first author)

10. Jingshu Xiao #, Jiaming Liang #, Junjie Fan, Panpan Hou, Xiaodong Li, Haipeng Zhang, Kai Li, Lang Bu, Ping Li, Miao He, Yongheng Zhong, Liping Guo, Penghui Jia, Qiaoqiao Xiao, Junyu Wu, Hong Peng, Chunmei Li, Fan Xing, Deyin Guo, CDK4/6 Inhibition Enhances Oncolytic Virus Efficacy by Potentiating Tumor-Selective Cell Killing and T-cell Activation in Refractory Glioblastoma. Cancer Research. 2022 Sep 16;82(18):3359-3374.

11. Hong Peng, Birong Zheng, Sidi Yang, Jie Du, Liu Cao, Lihong Liu, Zengyi Ma, Junyu Wu, Chunmei Li, Hailong Zhang, Deyin Guo, A soluble DR5-Fc chimeric protein attenuates inflammatory responses induced by coronavirus MHV-A59 and SARS-CoV-2. Journal of Medical Virology. 2022 Nov;94(11):5574-5581.

12. Lang Bu #, Huan Wang #, Ji-An Pan, Lang Chen, Fan Xing, Junyu Wu, Shun Li, Deyin Guo, PTEN suppresses tumorigenesis by directly dephosphorylating Akt, Signal Transduction and Targeted Therapy, 2021 Jul 12; 6(1):262.

13. Panpan Hou, Kongxiang Yang, Penghui Jia, Lan Liu, Yuxin Lin, Zibo Li, Jun Li, Shuliang Chen, Shuting Guo, Ji'An Pan, Junyu Wu, Hong Peng, Weijie Zeng, Chunmei Li, Yingfang Liu, Deyin Guo, A novel selective autophagy receptor, CCDC50, delivers K63 polyubiquitination-activated RIG-I/MDA5 for degradation during viral infection, Cell Research, 2021; 31(1):62-79.

14. Liping Guo, Xiaoyu Lu, Xue Liu, Ping Li, Junyu Wu, Fan Xing, Hong Peng, Xiaojun Xiao, Mang Shi, Zhigang Liu, Xiao-Dong Li, Deyin Guo, Meta-Transcriptomic Analysis Reveals the Virome and Viral Genomic Evolution of Medically Important Mites, Journal of Virology, 2020; 95(7):e01686-20.

15. Ye Zhang#, Jian-Feng Chang#, Jin Sun#, Lu Chen, Xiao-Mei Yang, Huan-Yin Tang, Yuan-Ya Jing, Xuan Kang, Zhi-Min He, Jun-Yu Wu, Hui-Min Wei, Da-Liang Wang, Rong-Gang Xu, Rui-Bao Zhu, Ying Shen, Shi-Yang Zeng, Chen Wang, Kui-Nan Liu, Yong Zhang, Zhi-Yong Mao, Ci-Zhong Jiang, Fang-Lin Sun*, Histone H3K27 methylation modulates the dynamics of FANCD2 on chromatin to facilitate NHEJ and genome stability. Journal of Cell Science, 2018; 131: jcs215525

16. Yang Gao, Maomao Chen, Junyu Wu, Yuan Zhou, Chuangjian Cai, Daliang Wang, Jianwen Luo, Facilitating in vivo tumor localization by principal component analysis based on dynamic fluorescence molecular imaging, Journal of Biomedical Optics, 2017; 22(9):1-9.

17. Lixia Pan#, Wenbing Xie#, Kai-Le Li, Zhihao Yang, Jiang Xu, Wenhao Zhang, Lu-Ping Liu, Xingjie Ren, Zhimin He, Junyu Wu, Jin Sun, Hui-Min Wei, Daliang Wang, Wei Xie, Wei Li, Jian-Quan Ni, and Fang-Lin Sun, Heterochromatin remodeling by CDK12 contributes to learning in Drosophila, Proc Natl Acad Sci U S A., 2015; 112 (45) 13988-13993.

18. Lei Zhao# , Haihui Gu# , Jianfeng Chang# , Junyu Wu, Daliang Wang, Su Chen, Xiaomei Yang , Baohua Qian, MicroRNA-383 regulates the apoptosis of tumor cells through targeting Gadd45g, PLoS One, 2014; 9(11):e110472.

19. Jie Qian, Junyu Wu, Bingbo Yao and Yanhua Lu, Preparation of a polyclonal antibody against hypericin synthase and localization of the enzyme in red-pigmented Hypericum , Acta Biochimica Polonica, 2012; 59(4):639-45.