中山大学医学院副教授、硕导。分别于2003年和2007年获得赫尔辛基大学生物系微生物学硕士和博士学位。2007年博士毕业后进入赫尔辛基大学医学院哈特曼研究所进行博士后训练，2010年转入赫尔辛基大学生物技术研究所工作。在赫尔辛基大学主要从事病原特别是细菌感染免疫致病机制研究，回国后主要研究病毒的感染复制与抗病毒免疫调控机制；以及利用电镜及3D重构技术研究内质网与生物大分子的动态变化及病毒互作机制。
招生学科专业：100100 基础医学-03 病原生物学，086000 生物与医药
主持或参与的科研项目：
1.深圳市科创委抗疫专项，2022/8-2023/7，中山大学主持人并获资助400万元
2.科技部国家重点研发计划， 2021/12-2024/12，参与
3.科技部重大专项，2017/01-2020/12,任务三负责人并获资助189万元
4.国家自然科学基金委重点国际合作项目，2017/01-2021/12，参与并获资助240万元
著作
1. Li, P#, Jiang, H#, Peng, H., Zeng, W., Zhong, Y., He, M., Xie, L., Chen, J., Guo, D., Wu, J.* & Li, C.M.*（2021）Non-structural protein 5 of Zika virus interacts with p53 in human neural progenitor cells and induces p53-mediated apoptosis. Virologica Sinica (accepted)
2. Bu, L#, Wang, H., Hou, P., Guo, S., He, M., Xiao, J., Li, P., Zhong, Y., Jia, P., Cao, Y., Liang, G., Yang, C., Chen, L., Guo, D.* & Li, C.M.* （2020）The ubiquitin E3 ligase parkin inhibits innate antiviral immunity through K48-linked polyubiquitination of RIG-I and MDA5. Front Immunol. 11:1926.
3. Zeng, W#, Lu, C., Shi, Y., Wu, C., Chen, X., Li, C.M. * & Yao, J. * (2020) Initiation of stress granule assembly by rapid clustering of IGF2BP proteins upon osmotic shock. Biochim Biophys Acta Mol Cell Res 1867(10):118795.
4. Cao, Y#, Wang, H., Yang, L., Zhang, Z., Li, C., Yuan, X., Chen, L., Chen, Y., Li, C.M.*& Guo, D.* (2017). PTEN-Long promotes type I interferon responses and antiviral immunity. Cellular & Molecular Immunology, doi: 10.1038/cmi.2017.102.
5. Zhou, J., Gao, G., Hou, P., Li, C.M.* & Guo, D*. (2017). Regulation of the Alternative Splicing and Function of Cyclin T1 by the Serine-Arginine-Rich Protein ASF/SF2. J. Cell Biochem.118(11), 4020-4032.
6. Wu, J. #, Wu, C. #, Xing, F#., Cao, L. #, Zeng, W., Guo, L., Li, P., Zhong, Y., Jiang, H., Luo, M., Shi, G., Bu, L., Ji, Y., Hou, P., Peng, H., Huang, J., Li, C.M., & Guo, D*. (2021) Endogenous reverse transcriptase and RNase H-mediated antiviral mechanism in embryonic stem cells. Cell Research (2021) 0:1–13;
7. Liu Cao, Tiefeng Xu, Xue Liu, Yanxi Ji, Siyao Huang, Hong Peng, Chunmei Li and Deyin Guo* (2022) The impact of accumulated mutations in SARS-CoV-2 variants on the qPCR detection efficiency. Frontiers in Cellular and Infection Microbiology 2022 Jan 28; 12:823306. doi: 10.3389/fcimb.2022.823306.
8. Junyu Wu#,*, Yongheng Zhong#, Xue Liu, Xiaoyu Lu, Weijie Zeng, Chunyan Wu, Fan Xing, Liu Cao, Fuxiang Zheng, Panpan Hou, Hong Peng, Chunmei Li, Deyin Guo* (2022) A novel phosphorylation site in SARS-CoV-2 nucleocapsid regulates its RNA-binding capacity and phase separation in host cells. Journal of Molecular Cell Biology 2022 Jan 18: mjac003. doi: 10.1093/jmcb/mjac003. Online ahead of print.
9. Fan Xing*, Jingshu Xiao*, Junyu Wu*, Jiaming Liang, Xiaoyu Lu, Liping Guo, Ping Li, Panpan Hou, Chunmei Li, Deyin Guo* (2021) Modulating the tumor microenvironment via oncolytic virus and PI3K inhibition synergistically restores immune checkpoint therapy response in PTEN-deficient glioblastoma. Signal transduction and Targeted Therapy 2021 Jul 28;6(1):275. doi: 10.1038/s41392-021-00609-0
10. Hou, P#, Jia, P#, Yang, K#, Li, Z., Tian, T., Lin, Y., Zeng, W., Xing, F., Chen, Y., Li, C.M., Liu, Y., & Guo, D*. (2021). An unconventional role of an ASB family protein in NF-κB activation and inflammatory response during microbial infection and colitis，Proc Natl Acad Sci U S A. 118(3): e2015416118.
11. Hou, P#, Yang, K., Jia, P., Liu, L., Lin, Y., Li, Z., Li, J., Chen, S., Guo, S., Pan, J., Wu, J., Peng, H., Zeng, W., Li, C.M., Liu, Y., & Guo, D*. (2021) A novel selective autophagy receptor, CCDC50, delivers K63 polyubiquitination-activated RIG-I/MDA5 for degradation during viral infection，Cell Res. 31(1):62-79.
12. Cao, L#, Ji, Y., Zeng, L., Liu, Q., Zhang, Z., Guo, S., Guo, X., Tong, Y., Zhao, X., Li, C.M., Chen, Y.* & Guo, D.* (2019) P200 family protein IFI204 negatively regulates type I interferon responses by targeting IRF7 in nucleus，PLoS Pathog. 15(10):e1008079. doi: 10.1371/journal.ppat.1008079. eCollection
13. Li, S#, Zhu, M., Pan, R., Fang, T., Cao, YY., Chen, S., Zhao, X., Lei, CQ., Guo, L., Chen, Y., Li, C.M., Jokitalo, E., Yin, Y., Shu, H., & Guo, D*. (2016) The tumor suppressor PTEN plays a critical role in antiviral innate immunity. Nat Immunol., 17, 241-249.
14. Leskinen, K#., Varjosalo, M., Li, Z., Li, C.M., & Skurnik, M*. (2015). Expression of the yersinia enterocolitica O:3 LPSO-antigen and outer core gene clusters is RfaH-dependent. Microbiology, 161, 1282-1294.
15. Haapalainen, M#., Dauphin, A., Li, C.M., Bailly, G., Tran, D., Briand, J., & Taira, S. (2012). HrpZ harpins from different Pseudomonas syringae pathovars differ in molecular interactions and in induction of anion channel responses in Arabidopsis thaliana suspension cells. Plant Physiology and Biochemistry, 51, 168-174.
16. Haapalainen, M#., Engelhardt, S., Kuefner, I., Li, C.M., Nuernberger, T., Lee, J., & Taira, S. (2011). Functional mapping of harpin HrpZ of Pseudomonas syringae reveals the sites responsible for protein oligomerization, lipid interactions and plant defence induction. Molecular Plant Pathology, 12, 151-166.
17. Rabsztyn, K#., Kasperkiewicz, K., Duda, K. A., Li, C.M., Łukasik, M., Radziejewska-Lebrecht, J., & Skurnik, M. (2011). Characterization of anti-ECA antibodies in rabbit antiserum against rough Yersinia enterocolitica O: 3. Biochemistry, 76, 832-839.
18. Engelhardt, S#., Lee, J., Gäbler, Y., Kemmerling, B., Haapalainen, M., Li, C.M., & Nuernberger, T. (2009). Separable roles of the Pseudomonas syringae pv. phaseolicola accessory protein HrpZ1 in ion–conducting pore formation and activation of plant immunity. The Plant Journal, 57, 706-717.
19. Li, C.M#, Hienonen, E., Haapalainen, M., Kontinen, V. P., Romantschuk, M., & Taira, S. (2007). Type III secretion system-associated pilus of Pseudomonas syringae as an epitope display tool. FEMS Microbiology Letters, 269, 104-109.
20. Li, C.M#, Haapalainen, M., Lee, J., Nürnberger, T., Romantschuk, M., & Taira, S. (2005). Harpin of Pseudomonas syringae pv. phaseolicola harbors a protein binding site. Molecular Plant-Microbe Interactions, 18, 60-66.
21. Li, C.M#, Brown, I., Mansfield, J., Stevens, C., Boureau, T., Romantschuk, M., & Taira, S. (2002). The Hrp pilus of Pseudomonas syringae elongates from its tip and acts as a conduit for translocation of the effector protein HrpZ. The EMBO Journal, 21, 1909-1915.
