杨中汉

电子邮件

yangzhh@mail.sysu.edu.cn

个人简介：

2004-2007年毕业于中山大学中山医学院，获生化与分子生物学博士学位
2001-2004年中山大学中山医学院生化教研室工作，助教
2004-2009年中山大学中山医学院生化教研室工作，讲师
2010-2012年在美国马里兰大学医学院从事博士后研究工作，USDA人类营养学研究中心访问学者
2010-2019年中山大学中山医学院生化教研室工作，副教授
2019-2022，中山大学医学院，副教授
2022-至今，中山大学医学院，教授

主要学术研究成果与贡献：

致力于免疫代谢关键模型研发及内外源免疫代谢关键分子研究，探究单核-巨噬细胞等免疫细胞参与的免疫炎症、脂肪细胞/肝细胞等营养性细胞参与的代谢调控、上皮细胞/免疫细胞参与的粘膜保护、内皮细胞/肿瘤细胞等参与的肿瘤血管增生等，聚焦代谢性炎症的免疫代谢机制研究、黏膜免疫与益生工程菌调节代谢稳态等。在eLife、PLoS Biology、Cell Mol Immunol、Fundamental Res等国际期刊上发表论文多篇，发现了内源性粘膜免疫分子IL-25通过极化巨噬细胞、增强线粒体呼吸容量、诱导脂肪米色化改善代谢稳态而有助于防治肥胖、糖尿病等代谢综合征；证实内源性生理活性小分子消退素、外源性小分子丹参酮及其化学修饰衍生物调节糖脂代谢的免疫代谢效应及其信号通路；新近发现黏附分子类孤儿受体信号通路调控脂肪产热与机体代谢稳态，为肥胖防治潜在靶点。

学术兼职及服务：

广东省生物化学与分子生物学常务理事，广东省精准医学应用学会疾病模型分会委员；国家自然科学基金通讯评审专家、广东省自然科学基金通讯评审专家、广东省医学科学基金通讯评审专家；Biochemical Pharmacology、Molecules、World Journal of Surgical Oncology等SCI杂志审稿人

研究方向：心血管与代谢综合征的免疫代谢机制；黏膜免疫与益生工程菌调节代谢稳态

招生学科专业：基础医学-分子医学专业（100100）学术博士/硕士；生物与医药（086000）专业博士/硕士。

联系方式：yangzhh@mail.sysu.edu.cn

著作(近5年来)

1.   Zewei Zhao, Longyun Hu, Bigui Song, Tao Jiang, Qian Wu, Jiejing Lin, Xiaoxiao Li, Yi Cai, Jin Li, Bingxiu Qian, Siqi Liu, Jilu Lang*, Zhonghan Yang*. The Role of ADGRA3 in Adipose Thermogenesis: A Potential Therapeutic Target for Obesity. eLife. (doi: https://doi.org/10.1101/2024.06.08.598066.)
2.   Zewei Zhao, Siqi Liu, Bingxiu Qian, Lin Zhou, Jianglin Shi, Junxi Liu, Lin Xu, Zhonghan Yang. CMKLR1 senses Chemerin/Resolvin E1 to control adipose thermogenesis and modulate metabolic homeostasis. Fundamental Research 2024, 4(3): 575-588. (https://doi.org/10.1016/j.fmre.2022.06.014.)
3.   Jianglin Shi, Zewei Zhao, Yong Huang*, Zhonghan Yang*. IL-25 Promotes Tumor Progression by Activating the AKT/mTOR Signaling Pathway in Bladder Cancer. Journal of Biological Regulators and Homeostatic Agents.2024, 38(7):5605-5617.
4.   Liu S, Zhang F, Liang Y, Wu G, Liu R, Li X, Saw PE, Yang Z. Nanoparticle (NP)-mediated APOC1 silencing to inhibit MAPK/ERK and NF-κB pathway and suppress breast cancer growth and metastasis. Sci China Life Sci. 2023 Aug 31. doi: 10.1007/s11427-022-2329-7.
5.   Zhao Z, Liu S, Luo S, Zhou L, Liu J, Qian B, Shi J, Zhou Y, Li J, Jiang T, Lv Z, Yang Z. IL-25 ameliorates acute cholestatic liver injury via promoting hepatic bile acid secretion. Cytokine. 2022 Oct;158:155979. doi:10.1016/j.cyto.2022.155979.
6.   Rui Shen, Lixin Ke, Qiao Li, Xi Dang, Shunli Shen, Jianing Shem, Shaoqiang Li, Lijian Liang, Baogang Peng*, Ming Kuang*, Yi Ma*, Zhonghan Yang*, Yunpeng Hua*. Abnormal bile acid‑microbiota crosstalk promotes the development of hepatocellular carcinoma. Hepatology International. 2022 Apr;16(2):396-411. doi: 10.1007/s12072-022-10299-7.
7.   Liu J, Qian B, Zhou L, Shen G, Tan Y, Liu S, Zhao Z, Shi J, Qi W, Zhou T, Yang X *, Gao G*, Yang Z*. IL25 Enhanced Colitis-Associated Tumorigenesis in Mice by Upregulating Transcription Factor GLI1. Frontiers in Immunology 2022 Mar 14;13:837262. doi: 10.3389/fimmu.2022.837262.
8.   Ma L#, Zhao Z#, Guo X#, Li J, Xu L, Mei W, Dong G, Zhong Z*, Yang Z*. Tanshinone IIA and its derivative activate thermogenesis in adipocytes and induce "beiging" of white adipose tissue. Mol Cell Endocrinol. 2022 Mar 15;544:111557.
9.   Li L#, Ma L#, Zhao Z#, Luo S, Gong B, Li J, Feng J, Zhang H, Qi W, Zhou T, Yang X, Gao G, Yang Z*. IL-25-induced shifts in macrophage polarization promote development of beige fat and improve metabolic homeostasis in mice. PLoS Biology. 2021 Aug 5;19(8):e3001348
10.   Li Q#, Ma L#, Shen S#, Guo Y#, Cao Q, Cai X, Feng J, Yan Y, Hu T, Luo S, Zhou L, Peng B*, Yang Z*, Hua Y*. Intestinal dysbacteriosis-induced IL-25 promotes development of HCC via alternative activation of macrophages in tumor microenvironment. J Exp Clin Cancer Res. 2019 Jul 11;38(1):303.
11.   Lel Ma#, Shiya Luo#, Lin Zhou#, Zewei Zhao, Qiao Li, Lin Xu, Baoyong Gong, Weiwei Qi, Ti Zhou, Xia Yang, Guoquan Gao*, Wenjie Mei*, Zhonghan Yang*. TanshinoneⅡA phenanthroimidazole derivative polarizes macrophage to improve metabolic homeostasis. Biochem Biophys Res Commun. 2019 Jun 30;514(3):861-867.
著作(2019年之前)：
12.   Juan Feng#, Lingyi Li#, Zhiying Ou#, Qiao Li, Zhenxian Zhao, Weiwei Qi, Ti Zhou, Jun Zhong, Weibin Cai, Xia Yang, Aiping Zhao, Guoquan Gao*, Zhonghan Yang*. IL-25 stimulates M2 macrophage polarization and thereby promotes mitochondrial respiratory capacity and lipolysis in adipose tissues against obesity. Cell Mol Immunol. 2018 May;15(5):493-505.
13.   Ma C#, Luo C#, Yin H, Zhang Y, Xiong W, Zhang T, Gao T, Wang X, Che D, Fang Z, Li L, Xie J, Huang M, Zhu L, Jiang P, Qi W, Zhou T, Zhonghan Yang, Wang W, Ma J, Gao G*, Yang X*. Kallistatin inhibits lymphangiogenesis and lymphatic metastasis of gastric cancer by downregulating VEGF-C expression and secretion. Gastric Cancer. 2018 Jul;21(4):617-631.
14.   Zhang T#, Yin P#, Zhang Z, Xu B, Che D, Dai Z, Dong C, Jiang P, Hong H, Zhonghan Yang, Zhou T, Shao J, Xu Z, Yang X, Gao G. Deficiency of pigment epithelium-derived factor in nasopharyngeal carcinoma cells triggers the epithelial-mesenchymal transition and metastasis. Cell Death Dis. 2017 Jun 1;8(6):e2838.
15.   Ma C#, Yin H#, Zhong J, Zhang Y, Luo C, Che D, Fang Z, Li L, Qin S, Liang J, Qi W, Zhonghan Yang, Zhou T, Ma J, Yang X, Gao G. Kallistatin exerts anti-lymphangiogenic effects by inhibiting lymphatic endothelial cell proliferation, migration and tube formation. Int J Oncol. 2017 Jun;50(6):2000-2010.
16.   Pei C, Zhao C, Wang AJ, Fan AX, Grinchuk V, Smith A, Sun R, Xie Y, Lu N, Urban JF Jr, Shea-Donohue T, Zhao A*, Zhonghan Yang*. A critical role for IL-25 in host protective Th2 memory response against Heligmosomoides polygyrus bakeri. Infect Immun. 2016 Nov 18;84(12):3328-3337.
17.   Wang AJ#, Zhonghan Yang#, Grinchuk V, Smith A, Qin B, Lu N, Wang D, Wang H, Ramalingam TR, Wynn TA, Urban JF Jr, Shea-Donohue T, Zhao A*. IL-25 or IL-17E Protects against High-Fat Diet-Induced Hepatic Steatosis in Mice Dependent upon IL-13 Activation of STAT6. J Immunol. 2015 Nov 15;195(10):4771-80.
18.   Jiang R#, Cai XY#, Zhonghan Yang#, Yan Y, Zou X, Guo L, Sun R, Luo DH, Chen QY, Huang PY, Xiang YQ, Lu X, Wang L, Xia WX, Mai HQ, Chen MY. Elevated peripheral blood lymphocyte-to-monocyte ratio predicts a favorable prognosis in the patients with metastatic nasopharyngeal carcinoma. Chin J Cancer. 2015 Jun 10;34(1):23.
19.   An-Jiang Wang, Allen Smith, Yanfei Li, Joseph F Urban, Thirumalai R Ramalingam, Thomas A Wynn, Nonghua Lu, Terez Shea-Donohue, Zhonghan Yang*, Aiping Zhao*. Genetic deletion of IL-25 (IL-17E) confers resistance to dextran sulfate sodium-induced colitis in mice. Cell & Bioscience . 2014 Nov 26;4:72. doi: 10.1186/2045-3701-4-72.
20.   Li L, Yao YC, Gu XQ, Che D, Ma CQ, Dai ZY, Li C, Zhou T, Cai WB, Zhonghan Yang, Yang X, Gao GQ. Plasminogen kringle 5 induces endothelial cell apoptosis by triggering a voltage-dependent anion channel 1 (VDAC1) positive feedback loop. J Biol Chem. 2014 Nov 21;289(47):32628-38.
21.   Hong H, Zhou T, Fang S, Jia M, Xu Z, Dai Z, Li C, Li S, Li L, Zhang T, Qi W, Bardeesi AS, Zhonghan Yang, Cai W, Yang X, Gao G. Pigment epithelium-derived factor (PEDF) inhibits breast cancer metastasis by down-regulating fibronectin. Breast Cancer Res Treat. 2014 Nov;148(1):61-72.
22.   Gong Q, Qiu S, Li S, Ma Y, Chen M, Yao Y, Che D, Feng J, Cai W, Ma J, Yang X, Gao G*, Zhonghan Yang*. Proapoptotic PEDF functional peptides inhibit prostate tumor growth-A mechanistic study. Biochem Pharmacol. 2014, 92(3): 425-437.
23.   Jiang R#, Zhonghan Yang#, Luo DH, Guo L, Sun R, Chen QY, Huang PY, Qiu F, Zou X, Cao KJ, Mai HQ, Guo X, Qian CN, Hong MH, Chen MY*. Elevated apolipoprotein A-I levels are associated with favorable prognosis in metastatic nasopharyngeal carcinoma. Med Oncol. 2014 Aug;31(8):80. doi: 10.1007/s12032-014-0080-y.
24.   Dai Z, Zhou T, Li C, Qi W, Mao Y, Lu J, Yao Y, Li L, Zhang T, Hong H, Li S, Cai W, Zhonghan Yang, Ma J, Yang X, Gao G. Intracellular pigment epithelium-derived factor contributes to triglyceride degradation. Int J Biochem Cell Biol. 2013 Sep;45(9):2076-86.
25.   Dai Z, Qi W, Li C, Lu J, Mao Y, Yao Y, Li L, Zhang T, Hong H, Li S, Zhou T, Zhonghan Yang, Yang X, Gao G*, Cai W*. Dual regulation of adipose triglyceride lipase by pigment epithelium-derived factor: a novel mechanistic insight into progressive obesity. Mol Cell Endocrinol. 2013 Sep 5;377(1-2):123-34.
26.   Zhao A, Zhonghan Yang, Sun R, Grinchuk V, Netzel-Arnett S, Anglin IE, Driesbaugh KH, Notari L, Bohl JA, Madden KB, Urban JF Jr, Antalis TM, Shea-Donohue T. SerpinB2 Is Critical to Th2 Immunity against Enteric Nematode Infection. J Immunol. 2013, 190(11):5779-87.
27.   Yao Y, Li L, Huang X, Gu X, Xu Z, Zhang Y, Huang L, Li S, Dai Z, Li C, Zhou T, Cai W, Zhonghan Yang, Gao G, Yang X. SERPINA3K induces apoptosis in human colorectal cancer cells via activating the Fas/FasL/caspase-8 signaling pathway.   FEBS J. FEBS J. 2013 Jul;280(14):3244-55.
28.   Cheng R, Li C, Li C, Wei L, Li L, Zhang Y, Yao Y, Gu X, Cai W, Zhonghan Yang, Ma J, Yang X, Gao G. The Artemisinin derivative Artesunate inhibits corneal neovascularization by inducing ROS-dependent apoptosis in vascular endothelial cells. Invest Ophthalmol Vis Sci. 2013, 15;54(5):3400-9.
29.   Zhonghan Yang, Grinchuk V, Urban JF Jr, Bohl J, Sun R, Notari L, Yan S, Ramalingam T, Keegan AD, Wynn TA, Shea-Donohue T, Zhao A*. Macrophages as IL-25/IL-33-Responsive Cells Play an Important Role in the Induction of Type 2 Immunity. PLoS One. 2013, 8(3):e59441.
30.   Zhonghan Yang, Grinchuk V, Smith A, Qin B, Bohl JA, Sun R, Notari L, Zhang Z, Sesaki H, Urban JF Jr, Shea-Donohue T, Zhao A*. Parasitic Nematode-Induced Modulation of Body Weight and Associated Metabolic Dysfunction in Mouse Models of Obesity. Infect Immun. 2013, 81(6):1905-14.
31.   Li C, Li L, Cheng R, Dai Z, Li C, Yao Y, Zhou T, Zhonghan Yang, Gao G, Yang X. Acidic/Neutral Amino Acid Residues Substitution in NH2 Terminal of Plasminogen Kringle 5 Exerts Enhanced Effects on Corneal Neovascularization. Cornea. 2013;32(5):680-688.
32.   Zhonghan Yang, Sun R, Grinchuk V, Blanco JA, Notari L, Bohl JA, McLean LP, Ramalingam TR, Wynn TA, Urban JF Jr, Vogel SN, Shea-Donohue T, Zhao A*. IL-33-induced alterations in murine intestinal function and cytokine responses are MyD88, STAT6, and IL-13 dependent. Am J Physiol Gastrointest Liver Physiol. 2013;304(4):G381-9.
33.   Dai Z, Lu L, Zhonghan Yang, Mao Y, Lu J, Li C, Qi W, Chen Y, Yao Y, Li L, Chen S, Zhang Y, Cai W, Yang X, Gao G. Kallikrein-binding protein inhibits LPS-induced TNF-α by upregulating SOCS3 expression. J Cell Biochem. 2013 , 114(5):1020-8.
34.   Zhonghan Yang, Viktoriya Grinchuk, Siu Po Ip,Chun-Tao Che, Harry H.S. Feng, Lixing Lao, Justin C.Wu, Joseph J.Sung, Brian Berman, Terez Shea-Donohue, and Aiping Zhao*. Anti inflammatory activities of a chinese herbal formula IBS-20 in vitro and in vivo. Evidence-Based Complementary and Alternative Medicine. 2012: 491496.
35.   Cai WB, Zhang Y, Cheng R, Wang Z, Fang SH, Xu ZM, Yang X, Zhonghan Yang, Ma JX, Shao CK, Gao GQ. al inhibition of plasminogen kringle 5 on angiogenesis and chemotaxis suppresses tumor metastasis by targeting HIF-1α pathway. PLoS One. 2012;7(12):e53152.
36.   Xu Z, Fang S, Zuo Y, Zhang Y, Cheng R, Wang Q, Zhonghan Yang, Cai W, Ma J, Yang X, Gao G. Combination of pigment epithelium-derived factor with radiotherapy enhances the antitumor effects on nasopharyngeal carcinoma by downregulating vascular endothelial growth factor expression and angiogenesis. Cancer Sci. 2011, 102(10):1789-98.
37.   Gu X, Yao Y, Cheng R, Zhang Y, Dai Z, Wan G, Zhonghan Yang, Cai W, Gao G, Yang X. Plasminogen K5 activates mitochondrial apoptosis pathway in endothelial cells by regulating Bak and Bcl-x(L) subcellular distribution. Apoptosis. 2011, 16(8):846-55.
38.   Zhang Y, Han J, Yang X, Shao C, Xu Z, Cheng R, Cai W, Ma J, Zhonghan Yang *, Gao G*. Pigment epithelium-derived factor inhibits angiogenesis and growth of gastric carcinoma by down-regulation of VEGF. Oncol Rep. 2011, 26(3):681-6.
39.   Zhao A, Urban JF Jr, Sun R, Stiltz J, Morimoto M, Notari L, Madden KB, Zhonghan Yang, Grinchuk V, Ramalingam TR, Wynn TA, Shea-Donohue T. Critical role of IL-25 in nematode infection-induced alterations in intestinal function. J Immunol. 2010, 185(11):6921-9.
40.   Qing Gong, Xia Yang, Weibin Cai, Guoquan Gao, Zhonghan Yang*. Expression and purification of functional epitope of pigment epithelium-derived factor in E.coli with inhibiting effect on endothelial cells. Protein Journal 2010, 29: 167-173.
41.   Yang X, Cai W, Xu Z, Chen J, Li C, Liu S, Zhonghan Yang, Pan Q, Li M, Ma J, Gao G. High efficacy and minimal peptide required for the anti-angiogenic and anti-hepatocarcinoma activities of plasminogen K5. J Cell Mol Med. 2010，14(10):2519-2530.
42.   Yang H, Cheng R, Liu G, Zhong Q, Li C, Cai W, Zhonghan Yang, Ma J, Yang X, Gao G . PEDF inhibits growth of retinoblastoma by anti-angiogenic activity. Cancer Sci 2009, 100(12): 2419-2425.
43.   Pan Q, Wu Y, Lin T, Yao H, Zhonghan Yang, Gao G, Song E, Shen H. Bone morphogenetic protein-2 induces chromatin remodeling and modification at the proximal promoter of Sox9 gene. Biochem Biophys Res Commun. 2009, 379(2): 356-61.
44.   Zhonghan Yang#, Xuehua Mo#, Qing Gong#, Qiuhui Pan, Xia Yang, Weibin Cai, Chaoyang Li, Jian-xing Ma, Yunshao He, Guoquan Gao*. Critical effect of VEGF in the process of endothelial cell apoptosis induced by high glucose. Apoptosis 2008, 13(11):1331-43.
45.   Zhu B, Lu L, Cai W, Yang X, Li C, Zhonghan Yang, Zhan W, Ma JX, Gao G. Kallikrein-binding protein inhibits growth of gastric carcinoma by reducing vascular endothelial growth factor production and angiogenesis. Mol Cancer Ther. 2007, 6(12 ):3297-306.
46.   Lu L#, Zhonghan Yang#, Yang X, Cai W, Li C, Ma JX, Gao G*. Kallikrein-binding protein suppresses growth of hepatocellular carcinoma by anti-angiogenic activity. Cancer Lett. 2007, 257(1):97-106.
47.   Yang X, Cheng R, Li C, Cai W, Ma JX, Liu Q, Zhonghan Yang, Song Z, Liu Z, Gao G. Kringle 5 of human plasminogen suppresses hepatocellular carcinoma growth both in grafted and xenografted mice by anti-angiogenic activity. Cancer Biol Ther. 2006 Apr;5(4):399-405.
48.   Wang QS, Yang X, Zhonghan Yang, Gao GQ. Novel method for expression and purification of human pigment epithelium-derived factor with biological activities in Escherichia coli. Prep Biochem Biotechnol. 2006;36(2):127-38.
49.   Cai W, Ma J, Li C, Zhonghan Yang, Yang X, Liu W, Liu Z, Li M, Gao G. Enhanced anti-angiogenic effect of a deletion mutant of plasminogen kringle 5 on neovascularization. J Cell Biochem. 2005, 96(6):1254-61.
50.   马雷, 李令一, 杨中汉. 免疫调控米色脂肪生成的研究进展[J]. 生命的化学, 2018,38(1)：128-134.
51.   马雷, 李令一, 杨中汉. 米色脂肪与疾病的关系及其意义[J]. 中国医药导报, 2017,14(25)：30-33.
52.   陈国军, 杨中汉，冯娟. 1型糖尿病的免疫机制研究进展[J]. 中国医药导报, 2017,14(32)：39-42.
53.   陈菲,罗创华，卢汉平，周倜，杨中汉，杨霞，高国全，齐炜炜. O2·-和H2O2表达上调对2型糖尿病患者血小板异常活化的影响[J]. 中山大学学报（医学科学版）, 2017,38(1)：56-62.
54.   徐祖敏，程锐，杨霞，杨中汉，刘少军，黎明涛，蔡卫斌，高国全。交叉酶切联合MALDI-TOF/MS分析重组蛋白二硫键分布的方法建立[J]。中山大学学报(自然科学版), 2011，50（5）：93-99.
55.   黄伟刚，高国全，杨中汉，陈福佳。色素上皮衍生因子在结直肠癌组织中的表达及临床意义。国际检验医学杂志，2010，2:113-114
56.   龚青，石丁波，蔡卫斌，杨中汉，谭维格，廖彩韵，彭超，刘畅，高国全，杨霞。藏红花素诱导宫颈癌HeLa 细胞凋亡及其作用机制。中华肿瘤防治杂志，2009，16（19）:1445-1447.
57.   杨中汉，李朝阳，杨霞,蔡卫斌，王青松，周世豪，邓春华，高国全，丘少鹏。管抑制因子在前列腺癌及前列腺增生组织中的表达及意义。中山大学学报(医学科学版)，2006，27（2）:126-129
58.   李朝阳，蔡卫斌，杨中汉，杨霞，宋志宏，周世豪，李明友，刘祖国，高国全。纤溶酶原K5抗血管增生活性依赖其完整Kringle结构域。中国生物化学与分子生物学报，2006，21（4）:625-656.
59.   蔡卫斌，杨中汉，李朝阳。银杏内酯B对谷氨酸诱导脑皮质神经元凋亡及Ca2+超载的影响。中国病理生理学杂志，2005，21（4）：652-656
60.   马建芳，杨中汉，李朝阳。纤溶酶原Kringle5缺失突变体抑制血管内皮细胞增生的研究第一军医大学学报 2003,23（12）
61.   蔡卫斌，李朝阳，杨中汉。人纤溶酶原K5突变体Ⅰ的构建及其在大肠杆菌中的表达与纯化。中山大学学报（医学科学版），2004，241-244
62.   马建芳，杨中汉，宋志宏。大剂量葡萄糖诱导人视网膜内皮细胞凋亡。第一军医大学学报，2003，23（5）：435-438
63.   林育芳，赵迎社，周羽並，郑辉，杨中汉。混合型高脂血症患者脂蛋白脂酶基因S447X的多态性。暨南大学学报，2002，23（5）：71-74
64.   赵迎社，杨中汉，冯建生。高脂血症患者脂蛋白脂酶基因外显子4区域变异的研究。遗传，2002，24（5）：519-522
65.   赵迎社，周羽并，林春兰，吴美玉，严玉霞，杨中汉，周天鸿。中国人混合型高脂血症患者脂蛋白脂酶常见基因变异的筛查。广东医学，2001，22(5):381-382
66.   杨中汉，冯建生。脱氧核酶:生物催化剂的新成员。生命的化学，2000，20（2）：55-57

奖励

1. 2023年度深圳市教育工作先进个人评选获“优秀班主任”（深圳市教育发展基金会）
2. 《围绕“器官-系统-功能”的新医科通专融合课程体系建设》中山大学教学成果二等奖，2023年，第三获奖人
3.《基于5G虚拟仿真技术的血管医学人才培养体系构建》中山大学附属第八医院第一届本科教育教学成果奖二等奖， 2023年，第三获奖人
4. 《以“器官-系统-功能”教学模式建设骨科临床教学基地》中山大学教学成果一等奖，2021年，第五获奖人
5. 《五年制临床医学专业“基础+临床”双班主任制度的探索与实践》中山大学教学成果一等奖，2021年，第三获奖人
6. “中山大学优秀班主任”称号（2020年度）
7.第六届（2020年）全国大学生基础医学创新研究暨实验设计论坛一等奖项目指导教师
8. “中山大学优秀硕士生导师”称号（2019年度）
9. 第九届中山医学院学术节主题报告“Immunometabolism reprograms fat beige” 获奖证书 2017年度
10. 第六届中山医学院学术节“青年学术奖（学术墙报组）” “Proapoptotic PEDF functional peptides inhibit prostate tumor growth – A mechanistic study” 一等奖 2014年度
11. 第五届中山医学院学术节“青年学术奖（学术墙报组）” “Parasitic Nematode-Induced Modulation of Body Weight and Associated Metabolic Dysfunction in Mouse Models of Obesity” 一等奖 2013年度
12．第四届中山医学院学术节“青年学术奖（学术报告组）” 二等奖 2012年度
13．人纤溶酶原K5及其突变体治疗血管增生性疾病的作用及分子机制。广东省科学技术自然科学二等奖（2009年，第五获奖人）。
14．首届中山医学院学术节青年学术奖优胜奖 2009年度
15．中山大学中山医学院第四届中文授课比赛三等奖 2008年度
16．优质在线课程《生物化学与分子生物学进展》三等奖2008年度

发明专利

1、发明专利名称：一种丹参酮IIA衍生物TAN20及其制备方法和应用（专利号：ZL 2019 1 0363875.0）
发明人：杨中汉；梅文杰；马雷；赵泽伟；罗诗雅；周琳
2、发明专利名称：一种新型微肽LBAMP1及其在结直肠癌治疗中的应用（专利号：202311270488.5）
发明人：杨中汉，钱炳秀，赵泽伟，李锦，刘斯琦，胡龙云，宋必贵，李肖肖，江涛
3、发明专利名称：G蛋白偶联受体ADGRA3及橙皮素在制备促进脂肪棕色化药物中的应用（申请号：2024106101508）
发明人：杨中汉，赵泽伟，李锦，江涛，李肖肖，胡龙云，宋必贵

参编教材

1. 副主编，《生物化学与分子生物学实验》（人民卫生出版社 2021年3月第一版，ISBN 978-7-117-31316-2）
2. 副主编，《生物化学与分子医学精要速览》(中国医药科技出版社，2018年第一版，ISBN 978-7-5214-0572-9）
3. 副主编，《生物化学与分子医学同步习题集》(中国医药科技出版社，2018年12月第一版，ISBN 978-7-5214-0588-0）
4. 编委，《分子医学技能》（科学出版社，2006年第一版，ISBN 7-03-017123-3）
5. 编委，《英汉生物化学与分子医学词典》（中国医药科技出版社，2004年第一版，ISBN7-5067-2803-6）