李昕博士，现任中山大学医学院教授，博士生导师。2005年于西北农林科技大学获得遗传学硕士学位（基地班本硕连读）。2008年于中科院昆明动物研究所获得博士学位（进化基因组，导师王文研究员）。2012年赴约翰霍普金斯大学医学院表观遗传研究中心从事人类复杂疾病及肿瘤的表观遗传学分子机制的研究。2017年8月获聘中山大学“百人计划”引进人才。
李昕博士自2005年起一直从事基因组与表观基因组的研究，利用生物信息学和实验生物学的手段回答重要的生物学问题。在对肿瘤发生和转移过程中，以及生物进化过程中的表观遗传学机制研究中均取得了突破性的成果。已发表多篇论文在《Nature Genetics》，《Nature Biotechnology》，《Science Advances》,《Genome Research》，《The American Journal of Human Genetics》，《Trends in Genetics》等国际著名杂志上。过去五年中，所有发表论文总引用数已超过2000次。
联系方式： lixin253@mail.sysu.edu.cn
主要研究方向
1. 表观遗传修饰（DNA甲基化/羟甲基化/组蛋白修饰）与基因表达调控
2. 新测序技术（单细胞测序，三代测序）在生物医学研究中的应用
3. 肿瘤发生和转移过程中表观调控重要基因的功能研究
招生与招聘
欢迎具有生物信息学、生物化学和分子生物学、基础医学等相关背景且热爱科学研究的同学报考硕士和博士研究生。有意者请发详细个人简历到本人邮箱提前联系。我们将提供最好的科研实验条件，瞄准国际前沿的研究课题，系统全面训练研究生的综合科研能力。鼓励研究生参加国内外的学术会议以提高专业素质，以使每一位研究生有机会作出第一流的研究工作，努力为你们未来职业发展提供最好的平台。研究生招生信息详见中山大学研究生招生网（http://graduate.sysu.edu.cn/gra02/）。
招生学科专业：071000 生物学-07 遗传学，10 生物化学与分子生物学，Z1 生物信息学
本实验室长期招聘博士后。
著作
代表性论文（共同一作#，通讯作者*）
Zou DD#, Sun YZ#, Li XJ, Wu WJ, Xu D, He YT, Qi J, Tu Y, Tang Y, Tu YH, Wang XL, Li X, Lu FY, Huang L, Long H, He L*, Li X*. Single-cell sequencing highlights heterogeneity and malignant progression in actinic keratosis and cutaneous squamous cell carcinoma. eLife. 2023, 12:e85270
Yang Q#, Cao Q#, Yu Y, Lai, XX, Feng JH, Li XJ, Jiang YN, Sun, YZ, Zhou ZW*, Li X*. Epigenetic and transcriptional landscapes during cerebral cortex development in a microcephaly mouse model. Journal of Genetics and Genomics. 2023, https://doi.org/10.1016/j.jgg.2023.10.006.
Lai XQ#, Li R#, Wang PP, Li M, Xiao CX, Cao Q, Li X*, Zhao WX*. Cumulative effects of weakly repressive regulatory regions in the 3’ UTR maintain PD-1 expression homeostasis in mammals. Communications Biology. 2023, 6:537.
Lu Y#, Cao Q#, Yu Y, Sun YZ, Jiang X*, Li X*. Pan-cancer analysis revealed H3K4me1 at bivalent promoters premarks DNA hypermethylation during tumor development and identified the regulatory role of DNA methylation in relation to histone modifications. BMC Genomics. 2023, 24(1):235.
Yu Y#, Li XJ#, Jiao R, Lu Y, Jiang X*, Li X*. H3K27me3-H3K4me1 transition at bivalent promoters instructs lineage specification in development. Cell & Bioscience. 2023, 13(1):1-20.
Xu PF#, Li C#, Chen YS, Li DP, Xi SY, Chen FR, Li X*, Chen ZP*. Radiomics-based survival risk stratification of glioblastoma is associated with different genome alteration. Computers in Biology and Medicine. 2023, 159:106878.
Li SS#, Yang Q#, Jiao R, Xu PF, Sun YZ* and Li X*. m6A Topological Transition Coupled to Developmental Regulation of Gene Expression During Mammalian Tissue Development. Front. Cell Dev. Biol. 2022, 10:916423.
Xu H#, Chen L#, Tong XL#, Hu H, Liu LY, Liu GC, Zhu YN, Zhao RP, Wang W, Dai FY*, Li X*, Xiang H*. Comprehensive silk gland multi-omics comparison illuminates two alternative mechanisms in silkworm heterosis. Zoological Research. 2022, 43(4):585-96.
Xu PF#, Li C#, Xi SY, Chen FR, Wang J, Zhang ZQ, Liu Y, Li X*, Chen ZP*. Whole exome sequencing reveals the genetic heterogeneity and evolutionary history of primary gliomas and matched recurrences. Computational and Structural Biotechnology Journal. 2022, 20:2235-2246
Shen J#, Xu YX#, Zhang S#, Lyu SZ#, Huo YY, Zhu YY, Tang KJ, Mou JL, Li XJ, Hoyle DL, Wang M, Wang JX*, Li X*, Wang ZZ*, Cheng T*. Single-cell transcriptome of early hematopoiesis guides arterial endothelial-enhanced functional T cell generation from human PSCs. Science Advances. 2021, 7:eabi9787
Li XJ, Feng JH, Sun YZ*, Li X*. An exploration of the tumor microenvironment identified a novel five-gene model for predicting outcomes in bladder cancer. Frontiers in Oncology. 2021, 11:642527
McDonald OG#, Li X#, Saunders T, Zacharias J, Stauffer KM, Mokohon-Moore A, Zhong Y, Poling JS, Timp W, Wu H, Iacobuzio-Donahue CA, Feinberg AP. Epigenomic reprogramming during pancreatic cancer progression links anabolic glucose metabolism to distant metastasis. Nature Genetics. 2017, 49:367-376
Li X, Liu Y, Salz T, Hansen KD, Feinberg AP. Whole genome analysis of the methylome and hydroxymethylome in normal and malignant lung and liver. Genome Research. 2016, 26:1730-1741
Liu Y#, Li X#, Aryee MJ, Ekstrom TJ, Padyukov L, Klareskog L, Vandiver A, Moore AZ, Tanaka T, Ferrucci L, Fallin MD, Feinberg AP. GeMes: Clusters of DNA methylation under genetic control can inform genetic and epigenetic analysis of disease. American Journal of Human Genetics. 2014, 94(4):485-95
Xiang H#, Li X#, Dai FY#, Xu X, Tan AJ, Chen L, Zhang GJ, Ding Y, Li QY, Lian JM, Willden A, Guo QH, Xia QY, Wang J, Wang W. Comparative methylomics between domesticated and wild silkworms implies possible epigenetic influences on silkworm domestication. BMC Genomics. 2013, 14:645
Li X#, Zhu JD#, Hu FY#, Ge S#, Ye M, Xiang H, Zhang GJ, Zheng XM, Zhang HY, Sun JH, Deng W, Luo RB, Yu C, Yu J, Sun JF, Zou XY, Cao XF, Xie XF, Wang J, Wang W. Single-base resolution maps of cultivated and wild rice methylomes and regulatory roles of DNA methylation in plant gene expression. BMC Genomics. 2012, 13:300
Xu X#, Liu X#, Ge S#, Jensen JD#, Hu FY#, Li X#, Dong Y#, Gutenkunst RN, Fang L, Huang L, Li JX, He WM, Zhang GJ, Zheng XM, Zhang FM, Li YR, Yu C, Kristiansen K, Zhang XQ, Wang J, Wright M, McCouch S, Nielsen R, Wang J, Wang W. Resequencing 50 accessions of cultivated and wild rice yields markers for identifying agronomically important genes. Nature Biotechnology. 2012, 30: 105-111
Xiang H#, Zhu JD#, Chen Q#, Dai FY#, Li X#, Li MW, Zhang HY, Zhang GJ, Li D, Dong Y, Zhao L, Lin Y, Cheng DJ, Yu J, Sun JF, Zhou XY, Ma KL, He YH, Zhao YX, Guo SC, Ye MZ, Guo GW, Li YR, Li RQ, Zhang XQ, Ma LJ, Kristiansen K, Guo QH, Jiang JH, Beck S, Xia QY, Wang W, Wang J. Single base–resolution methylome of the silkworm reveals a sparse epigenomic map. Nature Biotechnology. 2010, 28: 516-520
Li X, Zhao L, Jiang HF, Wang W. Short homologous sequences are strongly associated with the generation of chimeric RNAs in eukaryotes. Journal of Molecular Evolution. 2009, 68(1):56-65.
Li X#, Liang J#, Yu HJ, Su B, Xiao CJ, Shang YF, Wang W. Functional consequences of new exon acquisition in mammalian chromodomain Y-like (CDYL) genes. Trends in Genetics. 2007, 23(9): 427-431.
Li X, Yang S, Peng L, Chen H, Wang W. Origin and evolution of new genes. Chinese Science Bulletin. 2004, 49:1681-6.
