郭德银

职位

院长

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郭德银老师头像
  • 教授、博导,国家杰出青年基金获得者,国家“973”计划首席科学家,中国微生物学会病毒学专业委员会主委,国家创新人才推进计划重点领域创新团队负责人,广东省“珠江人才计划”引进第六批领军人才
  • 学科专业:微生物学/病毒学、病原生物学、分子生物学
  • 研究方向:冠状病毒感染致病机制与免疫调控机理,病毒基因治疗与抗病毒药物筛选
  • 分工:主持学院行政全面工作,分管财务、人事、人才引进、学科建设、国际交流。
  • 联系方式:guodeyin@mail.sysu.edu.cn

著作

1. Dan Liu, Lei Cui, Yuan Wang, Guifang Yang, Ruidong Hao, Jing He, Chengpeng Fan, Mengmeng Qu, Zhepeng Liu, Min Wang, Lang Chen and Deyin Guo* (2016) HBV e antigen and its precursors promote the progress of hepatocellular carcinoma by interacting with NUMB and decreasing p53 stability and activity. Hepatology 64, 390-404. 2016 Apr 22. doi: 10.1002/hep.28594. [Epub ahead of print]

2. Shun Li, Mingzhu Zhu, Ruangang Pan, Ting Fang, Yuan-Yuan Cao, Shuliang Chen, Xiaolu Zhao, Cao-Qi Lei, Lin Guo, Yu Chen, Chunmei Li, Eija Jokitalo, Yuxin Yin, Hong-Bing Shu, Deyin Guo* (2016) The tumor suppressor PTEN has a critical role in antiviral innate immunity. Nature Immunology 17, 241-249. (Advance Online Publication on Dec. 21, 2015; With expert comment in the News & Views section of the same issue)

3. Yu Chen, Hui Cai, Ji’an Pan, Nian Xiang, Po Tien, Tero Ahola, Deyin Guo* (2009) Functional screen reveals SARS coronavirus nonstructural protein nsp14 as a novel cap N7 methyltransferase. Proceedings of the National Academy of Sciences of the United States of America 106, 3484-9.

4. Yu Chen, Ceyang Su, Min Ke, Xu Jin, Lirong Xu, Zhou Zhang, Andong Wu, Ying Sun, Zhouning Yang, Po Tien, Tero Ahola, Yi Liang, Xinqi Liu, Deyin Guo* (2011) Biochemical and structural insights into the mechanisms of SARS coronavirus RNA ribose 2'-O-methylation by nsp16/nsp10 protein complex. PLoS Pathogens 7(10): e1002294. doi:10.1371/journal.ppat.1002294.

5. Yi Wang, Ying Sun, Andong Wu, Shan Xu, Ruangang Pan, Cong Zeng, Xu Jin, Xingyi Ge, Zhengli Shi, Tero Ahola, Yu Chen*, Deyin Guo* (2015) Coronavirus nsp10/nsp16 methyltransferase can be targeted by nsp10-derived peptide in vitro and in vivo to reduce replication and pathogenesis. Journal of Virology 89, 8416-27.

6. Cong Zeng, Andong Wu, Yi Wang, Shan Xu, Yingke Tang, Xu Jin, Shilei Wang, Lei Qin, Ying Sun, Chengpeng Fan, Eric J. Snijder, Benjamin W. Neuman, Yu Chen,Tero Ahola and Deyin Guo* (2016) Identification and Characterization of a Ribose 2'-O-Methyltransferase Encoded by the Ronivirus Branch of Nidovirales. Journal of Virology 90(15):6675-85.

7. Lei Cui, Haiying Wang, Yanxi Ji, Jie Yang, Shan Xu, Xingyu Huang, Zidao Wang, Lei Qin, Po Tien, Xi Zhou, Deyin Guo*, Yu Chen* (2015) The nucleocapsid protein of coronaviruses acts as a viral suppressor of RNA silencing in mammalian cells. Journal of Virology 89, 9029-43.

8. Yu Chen, Jiali Tao, Ying Sun, Andong Wu, Ceyang Su, Guozhen Gao, Hui Cai, Su Qiu, Yingliang Wu, Tero Ahola, Deyin Guo* (2013) Structure-function analysis of SARS coronavirus RNA cap guanine-N7 methyltransferase. Journal of Virology 87, 6296-305.

9. Mingzhu Zhu, Ting Fang, Shun Li, Kun Meng, Deyin Guo* (2015) Bipartite nuclear localization signal controls nuclear import and DNA binding activity of interferon regulatory factor 3. Journal of Immunology 195, 289-97.

10. Ruidong Hao, Jing He, Xing Liu, Guozhen Gao, Dan Liu, Lei Cui, Guojun Yu, Wenhui Yu, Yu Chen, Deyin Guo* (2015) Inhibition of hepatitis B virus gene expression and replication by hepatocyte nuclear factor 6. Journal of Virology 89, 4345-55.

11. Panpan Hou, Shuliang Chen, Shilei Wang, Xiao Yu, Yu Chen, Meng Jiang, Ke Zhuang, Wenzhe Ho, Wei Hou, Jian Huang and Deyin Guo* (2015). Genome editing of CXCR4 by CRISPR/cas9 confers cells resistance to HIV-1 infection. Scientific Reports 2015 Oct 20;5:15577. doi: 10.1038/srep15577.

12. Miao Jiang, Pamela Österlund, Peter Sarin, Minna Poranen, Dennis Bamford, Deyin Guo* and Ilkka Julkunen* (2011) Innate immune responses in human monocyte-derived dendritic cells are highly dependent on the size and the 5'-phosphorylation of RNA molecules. Journal of Immunology 187, 1713-21.

13. Snawar Hussain, Ji’an Pan, Yu Chen, Yalin Yang, Jing Xu, Yu Peng, Ying Wu, Zhaoyang Li, Ying Zhu, Po Tien, Deyin Guo* (2005) Identification of novel subgenomic RNAs and noncanonical transcription initiation signals of severe acute respiratory syndrome coronavirus. Journal of Virology 79, 5288-95.